Foretinib | CAS No. 849217-64-7

Foretinib

Basic Information

View in Editor

CAS Number

849217-64-7

Molecular Formula

C34H34F2N4O6

Molecular Weight

632.66 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

828.475°C at 760 mmHg

Density

1.372

SMILES

View in Editor

COc1cc2c(ccnc2cc1OCCCN1CCOCC1)Oc1ccc(cc1F)NC(=O)C1(CC1)C(=O)Nc1ccc(cc1)F

InChI

InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)

InChIKey

CXQHYVUVSFXTMY-UHFFFAOYSA-N

LogP

5.7724000000000055

Topological Polar Surface Area

111.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

1010

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Foretinib (GSK1363089)
Foretinib
Foretinib (GSK1363089, GSK089, XL880,EXEL-2880)
Foretinib (GSK1363089, XL880)
GSK 1363089
N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)-oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
XL880
4-(4-(o-Methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-1-butanol dihydrochloride
4-(4-Hydroxy-4-(3,4,5-trimethoxyphenyl)butyl)-1-(o-methoxyphenyl)piperazine dihydrochloride
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol dihydrochloride
EXEL-2880
GSK089
GSK136308
N1-{3-fluoro-4-[(6-(methyloxy)-7-{[3-(4-morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
XL-880,Foretinib
GSK1363089
XL 880
EXEL 2880
81FH7VK1C4
GSK1363089G
N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
C34H34F2N4O6
88Z
n-(3-fluoro-4-((6-methoxy-7-(3-(4-morpholinyl)propoxy)-4-quinolinyl)oxy)phenyl)-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
N-(3-Fluoro-4-{[6-Methoxy-7-(3-Morphol

MDL Number

MFCD16038048

FAQ

What regulatory guidelines apply to Foretinib (CAS: 849217-64-7)?

Foretinib (CAS: 849217-64-7) must comply with various regulatory guidelines including GHS classification for hazardous chemicals, REACH regulations for European manufacturers and importers, and FDA/EPA requirements for pharmaceutical and chemical manufacturing sites. Manufacturers should ensure compliance with local and international regulations to ensure safe handling and disposal.

Are there alternatives to Foretinib in synthesis?

There are alternative reagents and synthesis methods that can be used as substitutes to Foretinib (CAS: 849217-64-7). These include similar inhibitors such as crizotinib and pazopanib, which may be used in analogous synthetic routes. Researchers should evaluate the availability and cost-effectiveness of these alternatives based on specific chemical needs and regulatory requirements.

What is the market or research trend for Foretinib (CAS: 849217-64-7)?

The market for Foretinib (CAS: 849217-64-7) is showing steady growth due to its applications in targeted cancer therapies. Research trends are focused on understanding its efficacy in various cancer types and developing further formulations. Market demand is expected to increase as more clinical trials confirm its therapeutic benefits and safety profile.

How should waste containing Foretinib (CAS: 849217-64-7) be handled?

Waste containing Foretinib (CAS: 849217-64-7) should be collected and disposed of according to local and international hazardous waste regulations. Proper waste management involves ensuring that waste is stored in appropriate containers, labeled, and transported by licensed professionals. Incineration is a common method for disposing of hazardous chemical waste, but it should be conducted in a controlled and environmentally safe manner to prevent pollution.