5-Bromo-3-chloro-2-methoxypyridine

Basic Information

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CAS Number

848366-28-9

Molecular Formula

C6H5BrClNO

Molecular Weight

222.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

58.0 to 62.0 deg-C

Boiling Point

219.3℃ at 760 mmHg

Water Solubility

Slightly soluble in water.

SMILES

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COc1ncc(Br)cc1Cl

InChI

InChI=1S/C6H5BrClNO/c1-10-6-5(8)2-4(7)3-9-6/h2-3H,1H3

InChIKey

XCHXNAQRMMXBGN-UHFFFAOYSA-N

LogP

2.506100000000001

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

114

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

5-Bromo-3-chloro-2-methoxypyridine
2-Methoxy-3-chloro-5-bromopyridine
5-Bromo-3-chloro-2-methoxy-pyridine
5-BROMO-3-CHLORO-2-METHOXYPYRIDINE,98
Pyridine, 5-bromo-3-chloro-2-methoxy-
PubChem1164
XCHXNAQRMMXBGN-UHFFFAOYSA-N
AB20950
Pyridine,5-bromo-3-chloro-2-methoxy-
LS00025
AM62386
BC002089

MDL Number

MFCD04972382

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Bromo-3-chloro-2-methoxypyridine (CAS: 848366-28-9)?

5-Bromo-3-chloro-2-methoxypyridine is a crystalline solid with a molecular weight of approximately 256.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and ethanol. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It can also undergo oxidative deamination under appropriate conditions.

How is 5-Bromo-3-chloro-2-methoxypyridine (CAS: 848366-28-9) typically synthesized?

5-Bromo-3-chloro-2-methoxypyridine is typically synthesized through a multistep process involving the bromination of 3-chloro-2-methoxypyridine followed by a methylation step. This process often uses phosphorus tribromide as a brominating agent and a suitable catalyst such as aluminum chloride. High selectivity and good yield are achievable under optimized reaction conditions.

What industries use 5-Bromo-3-chloro-2-methoxypyridine (CAS: 848366-28-9)?

5-Bromo-3-chloro-2-methoxypyridine is primarily used in the pharmaceutical industry for the synthesis of various compounds, particularly as a precursor in the development of new drugs. It also finds applications in sensor systems and as an intermediate in the production of certain dyes and pigments.

What precautions should be taken when handling 5-Bromo-3-chloro-2-methoxypyridine (CAS: 848366-28-9)?

When handling 5-Bromo-3-chloro-2-methoxypyridine, appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.