(5-Amino-2-fluorophenyl)methanol

Basic Information

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CAS Number

84832-00-8

Molecular Formula

C7H8FNO

Molecular Weight

141.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

99-100°

Boiling Point

295.4°C at 760 mmHg

Density

1.286

Flash Point

132.5°C

Refractive Index

1.588

SMILES

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Nc1ccc(F)c(CO)c1

InChI

InChI=1S/C7H8FNO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4,9H2

InChIKey

NBVPTQRFNRBXGB-UHFFFAOYSA-N

LogP

0.9002000000000001

Topological Polar Surface Area

46.25 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

110

Safety Information

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Hazard Statement

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

(5-Amino-2-fluorophenyl)methanol
5-amino-2-fluoro benzyl alcohol
Benzenemethanol,5-amino-2-fluoro-
3-hydroxymethyl-4-fluoroaniline
5-AMINO-2-FLUOROBENZYL ALCOHOL
(5-Amino-2-fluoro-phenyl)-methanol
NBVPTQRFNRBXGB-UHFFFAOYSA-N
(5-amino-2-fluorophenyl)-methanol
SBB086192
3074AC
(3-amino-6-fluorophenyl)methan-1-ol
(5-azanyl-2-fluoranyl-phenyl)methanol
AB0049549

MDL Number

MFCD03094257

Customs Code

2922199090

FAQ

What are the physical and chemical properties of (5-Amino-2-fluorophenyl)methanol (CAS: 84832-00-8)?

(5-Amino-2-fluorophenyl)methanol (CAS: 84832-00-8) is a colorless to white crystalline solid with a molecular weight of approximately 170.03 g/mol. It is slightly soluble in water and more soluble in organic solvents. This compound is known for its reactivity, particularly in nucleophilic substitution and condensation reactions. It has a melting point around 108-110°C and a boiling point around 245°C. It displays basic properties due to the amino group.

How is (5-Amino-2-fluorophenyl)methanol (CAS: 84832-00-8) typically synthesized?

(5-Amino-2-fluorophenyl)methanol (CAS: 84832-00-8) can be synthesized via the reduction of 5-fluoro-2-nitrophenol with a suitable reducing agent such as sodium borohydride. This process provides good yield and selectivity. Alternatively, it can be prepared by reacting 5-amino-2-fluorophenol with methanol in the presence of an acid catalyst. These methods are commonly used in organic synthesis laboratories.

What industries use (5-Amino-2-fluorophenyl)methanol (CAS: 84832-00-8)?

(5-Amino-2-fluorophenyl)methanol (CAS: 84832-00-8) is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It also finds applications in the polymer industry for the preparation of functional polymers and in the semiconductor industry for the fabrication of electronic materials. Additionally, it is used in the development of chemical sensors and as a precursor in some fine chemical processes.

What precautions should be taken when handling (5-Amino-2-fluorophenyl)methanol (CAS: 84832-00-8)?

When handling (5-Amino-2-fluorophenyl)methanol (CAS: 84832-00-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Work should be conducted in a well-ventilated area, preferably under a fume hood. Spills should be cleaned up with care using appropriate absorbents. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures. Storage should be in a cool, dry place away from direct sunlight and flammable materials.