2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate | CAS No. 847862-26-4

2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate

Basic Information

CAS Number

847862-26-4

Molecular Formula

C12H22N2O2

Molecular Weight

226.32 g/mol

AD

Basic Physical Properties

CC(C)(C)OC(=O)N[C@@H]1[C@@H]2CC[C@H]1CNC2

InChI

InChI=1S/C12H22N2O2/c1-12(2,3)16-11(15)14-10-8-4-5-9(10)7-13-6-8/h8-10,13H,4-7H2,1-3H3,(H,14,15)/t8-,9+,10-

InChIKey

HHYUNZXSGVNMOY-ILWJIGKKSA-N

LogP

1.5090999999999999

Topological Polar Surface Area

50.36 Ų

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

261

Synonyms & References

English

  • tert-butyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate
  • tert-Butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate
  • Carbamic acid, (8-syn)-3-azabicyclo[3.2.1]oct-8-yl-, 1,1-dimethylethylester
  • Tert-butyl N-[(1S,5S)-3-azabicyclo[3.2.1]octan-8-yl]carbamate
  • tert-butyl N-[anti-3-azabicyclo[3.2.1]octan-8-yl]carbamate

MDL Number

MFCD18583409

FAQ

What are the physical and chemical properties of 2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate (CAS: 847862-26-4)?

2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate is a crystalline solid with a molecular weight of approximately 222.27 g/mol. It has a low water solubility and is moderately soluble in organic solvents. This compound is known for its moderate reactivity, particularly in amide bond formation. It has a melting point of about 140-142°C.

How is 2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate (CAS: 847862-26-4) typically synthesized?

2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate can be synthesized via a multistep process involving the formation of a bicyclic aziridine followed by an amide coupling reaction. Commonly, a prolinol derivative reacts with an alkylated amino acid to form the desired compound. The process typically yields 80-85% pure product with good selectivity.

What industries use 2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate (CAS: 847862-26-4)?

2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate is primarily used in the pharmaceutical industry for the synthesis of certain pharmaceutical compounds. It also finds applications in the polymer industry for enhancing material properties and in the sensor and semiconductor industry for specific functional groups.

What precautions should be taken when handling 2-Methyl-2-proanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate (CAS: 847862-26-4)?

When handling 2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight and sources of ignition. Spills should be handled with care using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed instructions.

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