Boc-Lys(Fmoc)-OH

Basic Information

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CAS Number

84624-27-1

Molecular Formula

C26H32N2O6

Molecular Weight

468.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

93-98℃

Boiling Point

685.7℃ at 760 mmHg

Density

1.2100

Water Solubility

Soluble in dimethylformamide. Insoluble in water.

Specific Rotation

3.3 º (c=1% in ethyl acetate)

SMILES

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CC(C)(C)OC(=O)NC(CCCCNC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)C(=O)O

InChI

InChI=1S/C26H32N2O6/c1-26(2,3)34-25(32)28-22(23(29)30)14-8-9-15-27-24(31)33-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H,27,31)(H,28,32)(H,29,30)/t22-/m0/s1

InChIKey

JYEVQYFWINBXJU-QFIPXVFZSA-N

LogP

4.673300000000004

Topological Polar Surface Area

113.96000000000002 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

684

Synonyms & References

English

N-Boc-N'-Fmoc-L-Lysine
Boc-Lys(Fmoc)-OH
6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-(tert-butoxycarbonylamino)hexanoic acid
N-epsilon-FMOC-N-alpha-BOC-L-Lysine
(2S)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid
Boc-L-Lys(Fmoc)-OH
Boc-Lys(Fmoc)
N-EPSILON-FMOC-N-ALPHA-T-BOC-L-LYSINE
N2-Boc-N6-Fmoc-L-lysine
N-Boc-N -Fmoc-L-Lysine
(2S)-2-(tert-Butoxycarbonylamino)-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
BocLys(Fmoc)
PubChem14939
N
A-Boc-N
A-Fmoc-L-lysine
JYEVQYFWINBXJU-QFIPXVFZSA-N
N-a-Boc-N-Epsilon-Fmoc-L-lysine
STL557497
BBL103687
N-epsilon-FMOC-N
N-alpha-t-Butyloxycarbonyl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine
SCHEMBL999302
DS-15354
J-300173
Nalpha-tert-butoxycarbonyl-Nepsilon-(9-fluorenylmethoxycarbonyl)-L-lysine
N6-(((9H-fluoren-9-yl)methoxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysine
Nalpha-Boc-Nepsilon-Fmoc-L-lysine
DB-030150
CS-W005144
Boc-Lys(Fmoc)-OH, >=99.0% (sum of enantiomers, TLC)

MDL Number

MFCD00062032

FAQ

What is Boc-Lys(Fmoc)-OH (CAS: 84624-27-1)?

Boc-Lys(Fmoc)-OH is a protected lysine derivative used in peptide synthesis. Its chemical formula is C20H27N3O5S. It features a tert-butyl carbamoyl (Boc) group and a 9-fluorenylmethyloxycarbonyl (Fmoc) protecting group on the lysine amino acid. This compound is a solid at room temperature, slightly soluble in water, and stable under standard laboratory conditions. It is widely utilized in solid-phase peptide synthesis due to its controlled reactivity and ease of handling in organic solvents.

What are the main uses of Boc-Lys(Fmoc)-OH (CAS: 84624-27-1)?

Boc-Lys(Fmoc)-OH is primarily used in pharmaceutical research for synthesizing peptides and proteins. It serves as a key building block in drug development, particularly in creating peptide-based therapeutics. Additionally, it is employed in biochemistry for antibody engineering and in organic synthesis for functional group manipulation. Its applications also extend to academic research in protein structure studies and chemical modifications.

Is Boc-Lys(Fmoc)-OH (CAS: 84624-27-1) safe?

Boc-Lys(Fmoc)-OH is considered safe when handled properly. It has low toxicity and is not classified as hazardous under standard safety guidelines. However, protective measures such as gloves, safety goggles, and adequate ventilation are recommended during handling. Avoid direct skin contact and inhalation of powder. Always follow lab safety protocols and work with certified chemical suppliers to ensure compliance with safety standards.

How should Boc-Lys(Fmoc)-OH (CAS: 84624-27-1) be stored?

Boc-Lys(Fmoc)-OH should be stored in a cool, dry place (below 25°C), away from light and moisture. Keep in airtight containers, preferably glass or aluminum, to prevent degradation. Store in a desiccator for optimal stability. Avoid exposure to reactive chemicals and ensure proper labeling. Maintain storage conditions to preserve its integrity for extended use in synthesis processes.