(1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine

Basic Information

View in Editor

CAS Number

84499-73-0

Molecular Formula

C9H10F3N

Molecular Weight

189.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

149.6°C at 760 mmHg

Density

1.624

Flash Point

52.3°C

Refractive Index

1.285

SMILES

View in Editor

CC(C1=CC=C(C=C1)C(F)(F)F)N

InChI

InChI=1S/C9H10F3N/c1-6(13)7-2-4-8(5-3-7)9(10,11)12/h2-6H,13H2,1H3/t6-/m0/s1

InChIKey

GUMZDWPMXGQNBG-LURJTMIESA-N

LogP

2.7251000000000003

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

159

Safety Information

View Safety Information

Hazard Statement

Synonyms & References

English

84499-73-0
(S)-1-[4-(Trifluoromethyl)phenyl]ethylamine
(S)-alpha-Methyl-4-(trifluoromethyl)benzylamine
AKOS015840100
Y10214
(1S)-1-[4-(trifluoromethyl)phenyl]ethanamine
PS-8411
(1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine
AKOS010400805
AC-26381
CS-B0008
(s)-1-(4-(trifluoromethyl)phenyl)ethylamine
A840820
SCHEMBL335039
EN300-82560
(S)-1-(4-(trifluoromethyl)phenyl)ethanamine
(1S)-1-[4-(trifluoromethyl)phenyl]ethan-1-amine
GUMZDWPMXGQNBG-LURJTMIESA-N
MFCD03093009
DTXSID10381251
(S)-1-(4-(Trifluoromethyl)phenyl)ethanamine
Benzenemethanamine,a-methyl-4-(trifluoromethyl)-,(S)-
[(S)-1-[4-(Trifluoromethyl)phenyl]ethyl]amine

MDL Number

MFCD03093009

FAQ

What are the physical and chemical properties of (1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine (CAS: 84499-73-0)?

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine is a white crystalline solid with a molecular weight of approximately 215.12 g/mol. It has a low water solubility and is soluble in organic solvents such as ethanol and acetonitrile. It is a chiral compound with high reactivity towards nucleophiles and electrophiles due to the presence of the trifluoromethyl group, which enhances its lipophilicity and reactivity.

How is (1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine (CAS: 84499-73-0) typically synthesized?

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine can be synthesized via reductive amination of 4-(trifluoromethyl)benzaldehyde with ethylamine using a reducing agent like sodium triacetoxyborohydride and a catalyst such as 18-crown-6. The reaction is carried out in an organic solvent like methanol or acetonitrile, typically giving a yield of around 70-80%.

What industries use (1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine (CAS: 84499-73-0)?

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine is used in pharmaceuticals for its potential as an intermediate in the synthesis of various bioactive compounds. It is also utilized in the polymer industry as a modifier and in other sectors such as sensors and semiconductors for its unique chemical properties.

What precautions should be taken when handling (1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine (CAS: 84499-73-0)?

When handling (1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood due to its potential volatility. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly washed down. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.