(1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine(CAS: 84499-73-0)

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine is a white crystalline solid with a molecular weight of approximately 215.12 g/mol. It has a low water solubility and is soluble in organic solvents such as ethanol and acetonitrile. It is a chiral compound with high reactivity towards nucleophiles and electrophiles due to the presence of the trifluoromethyl group, which enhances its lipophilicity and reactivity.

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine can be synthesized via reductive amination of 4-(trifluoromethyl)benzaldehyde with ethylamine using a reducing agent like sodium triacetoxyborohydride and a catalyst such as 18-crown-6. The reaction is carried out in an organic solvent like methanol or acetonitrile, typically giving a yield of around 70-80%.

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine is used in pharmaceuticals for its potential as an intermediate in the synthesis of various bioactive compounds. It is also utilized in the polymer industry as a modifier and in other sectors such as sensors and semiconductors for its unique chemical properties.

When handling (1S)-1-[4-(Trifluoromethyl)phenyl]ethanamine, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood due to its potential volatility. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly washed down. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.