Lamotrigine | CAS No. 84057-84-1

Lamotrigine

Basic Information

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CAS Number

84057-84-1

Molecular Formula

C9H7Cl2N5

Molecular Weight

256.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

216.0 to 220.0 deg-C

Boiling Point

503.1 °C at 760 mmHg

Density

1.572

Solubility

DMSO: 20 mg/mL at 60 °C, soluble

SMILES

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Nc1nnc(c(N)n1)c2cccc(Cl)c2Cl

InChI

InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

InChIKey

PYZRQGJRPPTADH-UHFFFAOYSA-N

LogP

2.0097999999999994

pKa

5.7(at 25℃)

Topological Polar Surface Area

90.71 Å²

Hydrogen Bond Donor/Acceptor

4 / 5

Complexity

242

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Sensitiveness

Sensitive to heat and air

Toxicity

LD50 in mice, rats (mg/kg): 250, >640 orally (Sawyer)

Synonyms & References

English

6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
Lamotrigine
Lamotrigine solution
1,2,4-TRIAZINE-3,5-DIAMINE,6-(2,3-DICHLOROPHENYL)-
6-O-TRITYL-1,2,3,4-TETRA-O-ACETYL-ALPHA-D-MANNOPYRANOSE
BW430C
Crisomet
HYDROXYMETHYL PROGESTERONE
Labileno
Lamictal
Lamictal Cd
Lamictal XR
LAMOTRIGENE
Lamotrigin
Lamotrigina
LAMOTRIGINE (10 MG )
LAMOTRIGINE API
LAMOTRIGINE-13C3
Lamotriginum
LTG
GI 267119X
Lamotriginum [Latin]
Lamotrigina [Spanish]
Lamictal ODT
BW 430C
1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
C9H7Cl2N5
MLS000069685
PYZRQGJRPPTADH-UHFFFAOYSA-N

MDL Number

MFCD00865333

Customs Code

2933699090

FAQ

What is Lamotrigine (CAS: 84057-84-1)?

Lamotrigine (CAS: 84057-84-1) is an anticonvulsant medication primarily used to treat epilepsy. It works by reducing the excessive electrical activity in the brain that causes seizures. Its chemical formula is C13H12N2O2, and it is a white to off-white crystalline powder with good solubility in organic solvents. Lamotrigine is known for its ability to modulate voltage-gated sodium channels, making it effective in managing both focal and generalized seizures.

What are the main uses of Lamotrigine (CAS: 84057-84-1)?

Lamotrigine (CAS: 84057-84-1) is mainly used in pharmaceuticals to treat epilepsy, including partial-onset seizures and generalized tonic-clonic seizures. It is also prescribed as an adjunctive therapy for seizures in adults and children. Additionally, lamotrigine is used in the treatment of bipolar disorder to help manage manic episodes. Its applications are supported by its mechanism of action and safety profile in clinical settings.

Is Lamotrigine (CAS: 84057-84-1) safe?

Lamotrigine (CAS: 84057-84-1) is generally considered safe when used as directed, but it requires careful handling. It is approved for use in many countries and has a favorable risk-benefit profile. However, precautions should be taken to avoid skin irritation and ensure proper dosing. Safety standards include monitoring for adverse effects such as rash, and it is important to follow guidelines for its use in both medical and industrial contexts.

How should Lamotrigine (CAS: 84057-84-1) be stored?

Lamotrigine (CAS: 84057-84-1) should be stored in a cool, dry place away from direct light. It is typically kept in a sealed container at a temperature between 15°C to 30°C. Proper storage ensures stability and maintains its potency over time. Avoid exposure to moisture and heat to prevent degradation. Always follow manufacturer instructions for storage to ensure safe handling and effective use.