N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine

Basic Information

View in Editor

CAS Number

84000-07-7

Molecular Formula

C19H19NO4

Molecular Weight

325.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

156.0 to 160.0 deg-C

Density

1.2620

Water Solubility

Slightly soluble in water.

Specific Rotation

-18.5 º (c=1,DMF)

SMILES

View in Editor

CC(C(=O)O)N(C)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C19H19NO4/c1-12(18(21)22)20(2)19(23)24-11-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,12,17H,11H2,1-2H3,(H,21,22)/t12-/m0/s1

InChIKey

JOFHWKQIQLPZTC-LBPRGKRZSA-N

LogP

3.3404000000000016

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

458

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

CS-W008235
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-ALANINE
Fmoc-MeAla-OH
Fmoc-N-Me-Ala-OH
MFCD00153384
J-300018
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid
(2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid
L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-
A851138
F1164
AKOS015907196
HY-W008235
SCHEMBL120596
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-alanine
84000-07-7
DS-1128
EN300-766018
Fmoc-N-methyl-L-alanine
AC-8567
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine
Fmoc-Nalpha-methyl-L-alanine
Fmoc-N-a-methyl-L-alanine
M03350
AM20050373
Fmoc-L-MeAla-OH
N-fmoc-N-methylalanine
DTXSID00350931
Fmoc-N-Me-Ala-OH, >=97.0% (sum of enantiomers, HPLC)
N-Fmoc-N-methyl-L-alanine
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanoic acid

MDL Number

MFCD00153384

Customs Code

2922509090

FAQ

What are the physical and chemical properties of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine (CAS: 84000-07-7)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine is a white crystalline powder with a molecular weight of approximately 404.38 g/mol. It is sparingly soluble in water but soluble in organic solvents like methanol and dichloromethane. This compound is known for its reactivity towards nucleophiles and can undergo esterification reactions. It is stable under normal conditions but should be stored away from moisture and heat to preserve its integrity.

How is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine (CAS: 84000-07-7) typically synthesized?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine can be synthesized using a multi-step process involving the protection of the carboxylic acid group of alanine with fluorenylmethoxycarbonyl (Fmoc) group, followed by the introduction of a methyl group. This compound is often prepared using standard synthetic chemistry techniques, including coupling reactions, protecting group manipulations, and acid/base catalysis. The synthesis typically yields a product with a high degree of purity.

What industries use N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine (CAS: 84000-07-7)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine (CAS: 84000-07-7) is primarily used in the pharmaceutical industry for the synthesis of complex peptides and drug intermediates. It is also utilized in the polymer industry for the development of functional polymers with enhanced properties. Additionally, this compound finds applications in the production of sensors and in materials science due to its unique chemical properties.

What precautions should be taken when handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine (CAS: 84000-07-7)?

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylalanine (CAS: 84000-07-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents and disposed of in accordance with local regulations. Always consult the safety data sheet (SDS) for detailed handling and disposal information.