Lisinopril dihydrate

Basic Information

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CAS Number

83915-83-7

Molecular Formula

C21H35N3O7

Molecular Weight

441.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

148°C

Boiling Point

666.4°C at 760 mmHg

Solubility

H2O: ≥10 mg/mL

Refractive Index

-45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)

Specific Rotation

25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); 25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)

SMILES

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C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O

InChI

InChI=1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1

InChIKey

CZRQXSDBMCMPNJ-ZUIPZQNBSA-N

LogP

-0.41419999999999596

pKa

2.5, 4.0, 6.7, 10.1(at 25℃)

Topological Polar Surface Area

195.95999999999998 Å²

Hydrogen Bond Donor/Acceptor

9 / 10

Complexity

550

Safety Information

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Hazard Statement

H360 May damage fertility or the unborn child
Reproductive toxicity

H373 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Hazard Class

Class 6.1 Class 6.1

Stability

Hygroscopic

Sensitiveness

thermally sensitive

Synonyms & References

English

LISINOPRIL [USP MONOGRAPH]
ZESTORETIC COMPONENT LISINOPRIL
EN300-19652794
LISINOPRIL DIHYDRATE [MI]
MFCD01698825
LISINOPRIL DIHYDRATE [EP MONOGRAPH]
1ST10889W
LISINOPRIL [MART.]
CHEBI:6503
LISINOPRIL [USP-RS]
LISINOPRIL [ORANGE BOOK]
AC-6226
Lisinopril hydrate (JP17)
lisinopril-dihydrat
SCHEMBL542591
CAS-83915-83-7
BL164629
Lisinopril dihydrate
Lisinopril (USP)
Prinivil (TN)
NSC 758151
L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, dihydrate
Tox21_110798
DTXSID2045600
LISINOPRIL DIHYDRATE [WHO-DD]
(S)-Lisinopril
Lisinopril Dihydrate; N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline dihydrate; (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate
L-Proline, 1-(N2-(1-carboxy-3-phenylpropyl)-L-lysyl)-, dihydrate, (S)-
Q47495698
NCGC00017141-01
LISINOPRIL [HSDB]

MDL Number

MFCD01698825

FAQ

What is Lisinopril dihydrate (CAS: 83915-83-7)?

Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor used primarily in the treatment of hypertension and heart failure. Its chemical formula is C10H17N3O5S·2H2O, and it is a white, crystalline powder that is stable under normal conditions. It is commonly prescribed as a medication due to its effectiveness in lowering blood pressure and improving cardiac function.

What are the main uses of Lisinopril dihydrate (CAS: 83915-83-7)?

Lisinopril dihydrate is mainly used in pharmaceuticals to treat high blood pressure (hypertension), heart failure, and to improve survival after a heart attack. It is also used in research for studying cardiovascular diseases and in the development of related therapies. Its role as an ACE inhibitor makes it a key compound in the field of pharmacology and drug development.

Is Lisinopril dihydrate (CAS: 83915-83-7) safe?

Lisinopril dihydrate is generally considered safe when used as directed. However, it should be handled with care, especially in its raw form, to avoid skin contact or inhalation. Safety standards include proper storage and use of personal protective equipment. Side effects may occur, and it is important to follow medical guidelines to ensure safe usage.

How should Lisinopril dihydrate (CAS: 83915-83-7) be stored?

Lisinopril dihydrate should be stored in a cool, dry place away from moisture and light. It is typically kept in a sealed container at a temperature between 15°C to 30°C. Proper storage ensures stability and maintains the efficacy of the compound over time. Avoid exposure to extreme temperatures or humidity to prevent degradation.