5,6-Difluoro-1H-isoindole-1,3(2H)-dione

Basic Information

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CAS Number

83684-73-5

Molecular Formula

C8H3F2NO2

Molecular Weight

183.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

230-231°C

Density

1.578

SMILES

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C1=C2C(=CC(=C1F)F)C(=O)NC2=O

InChI

InChI=1S/C8H3F2NO2/c9-5-1-3-4(2-6(5)10)8(13)11-7(3)12/h1-2H,(H,11,12,13)

InChIKey

MROUYCSLODQSRN-UHFFFAOYSA-N

LogP

0.8484

Topological Polar Surface Area

46.17 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

243

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AS-50204
J-516523
SB64081
MFCD21103153
O11324
5,6-difluoroisoindole-1,3-dione
83684-73-5
EN300-38854
CHEMBL4547262
CS-0209989
5,6-Difluoroisoindoline-1,3-dione
5,6-difluoro-2,3-dihydro-1H-isoindole-1,3-dione
Z381556306
SCHEMBL1081926
4,5-difluorophthalimide
MROUYCSLODQSRN-UHFFFAOYSA-N
5,6-Difluoro-1H-isoindole-1,3(2H)-dione
AKOS009319150
5,6-DIFLUOROINDOLINE
5,6-difluoroindoline-2,3-dione
5,6-Difluoroisatin

MDL Number

MFCD21103153

Customs Code

2925190090

FAQ

What are the physical and chemical properties of 5,6-Difluoro-1H-isoindole-1,3(2H)-dione (CAS: 83684-73-5)?

5,6-Difluoro-1H-isoindole-1,3(2H)-dione (CAS: 83684-73-5) is a crystalline solid with a molecular weight of approximately 168.05 g/mol. It has a melting point of 228-230°C and a low solubility in water but is more soluble in common organic solvents like methanol and ethanol. It is relatively stable but can react with bases under certain conditions. This compound is often used in synthetic transformations due to its reactivity.

How is 5,6-Difluoro-1H-isoindole-1,3(2H)-dione (CAS: 83684-73-5) typically synthesized?

5,6-Difluoro-1H-isoindole-1,3(2H)-dione (CAS: 83684-73-5) is typically synthesized via the fluorination of 1H-isoindole-1,3(2H)-dione using a Lewis acid catalyst such as aluminum chloride. This method provides good selectivity and yield, making it a practical approach for industrial production.

What industries use 5,6-Difluoro-1H-isoindole-1,3(2H)-dione (CAS: 83684-73-5)?

5,6-Difluoro-1H-isoindole-1,3(2H)-dione (CAS: 83684-73-5) is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds applications in the chemical industry for the production of dyes and pigments. Its unique chemical properties make it valuable in research and development for various applications.

What precautions should be taken when handling 5,6-Difluoro-1H-isoindole-1,3(2H)-dione (CAS: 83684-73-5)?

When handling 5,6-Difluoro-1H-isoindole-1,3(2H)-dione (CAS: 83684-73-5), it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to prevent inhalation. Spills should be handled carefully, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.