2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole

Basic Information

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CAS Number

835-31-4

Molecular Formula

C14H14N2

Molecular Weight

210.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

254 °C

Boiling Point

440.466°C at 760 mmHg

Density

1.1063 (rough estimate)

Flash Point

220.2 ºC

Refractive Index

1.6180 (estimate)

SMILES

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C1CN=C(N1)CC2=CC=CC3=CC=CC=C32

InChI

InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)

InChIKey

CNIIGCLFLJGOGP-UHFFFAOYSA-N

LogP

2.3840000000000003

Topological Polar Surface Area

24.39 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

272

Synonyms & References

English

alpha-Naphthylmethyl imidazoline
KBio1_000456
BRN 0151864
Sanorin (Salt/Mix)
4,5-Dihydro-2-(1-naphthylmethyl)imidazole
Imidin
Prestwick2_000046
Clearine
Prestwick3_000046
2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole
2-(.alpha.-Naphthylmethyl)-imidazoline
BDBM50001922
BPBio1_000189
UNII-H231GF11BV
2-(Naphthyl-(1')-methyl)imidazolin [German]
CNIIGCLFLJGOGP-UHFFFAOYSA-N
KBio2_006591
NS00003424
2-(Naphthyl-(1')-methyl)imidazolin
1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-
AB00053505-12
Z56762888
NAPHAZOLINE [MART.]
Prestwick1_000046
Ciba 2020/R
835-31-4
Spectrum4_000068
NAPHAZOLINE (MART.)
NAPHAZOLINE [INN]
KBio2_004023
CS-0034952

MDL Number

MFCD00066737

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole (CAS: 835-31-4)?

2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole (CAS: 835-31-4) is a white or off-white crystalline solid with a molecular weight of approximately 216.23 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and methanol. Chemically, it is stable under normal conditions but can react with strong acids to form imidazoles. It has a pKa of about 10.2, indicating basicity.

How is 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole (CAS: 835-31-4) typically synthesized?

2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole is typically synthesized through a multistep process involving the reaction of 1-naphthylmethylamine with formaldehyde in the presence of a base such as sodium hydroxide. The reaction requires careful control of pH and temperature to ensure high yield and selectivity. The final step involves dehydration to form the imidazole ring.

What industries use 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole (CAS: 835-31-4)?

2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole (CAS: 835-31-4) is used in the pharmaceutical industry as a starting material for drug synthesis, particularly in the development of antiviral and anti-inflammatory agents. It is also used in the sensor industry for its ability to detect certain gases and in semiconductor applications due to its electronic properties.

What precautions should be taken when handling 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole (CAS: 835-31-4)?

When handling 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole (CAS: 835-31-4), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate safety procedures, and the material should be disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage information.