5-Bromo-2-chloro-3-fluoropyridine

Basic Information

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CAS Number

831203-13-5

Molecular Formula

C5H2BrClFN

Molecular Weight

210.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

50.0 to 54.0 deg-C

Boiling Point

195.3℃ at 760 mmHg

Density

1.829

Flash Point

71.9℃

Refractive Index

1.555

SMILES

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C1=C(C=NC(=C1F)Cl)Br

InChI

InChI=1S/C5H2BrClFN/c6-3-1-4(8)5(7)9-2-3/h1-2H

InChIKey

OEKXUEWGXWCENG-UHFFFAOYSA-N

LogP

2.6366000000000005

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

103

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

BCP22154
SCHEMBL16392
2-CHLORO-3-FLUORO-5-BROMOPYRIDINE
AKOS005063471
CS-D0950
AB14161
GS-6904
Q-103382
DTXSID80376871
A1-53413
B5089
N-Benzylbenzo[d]isothiazol-3-amine
5-Bromo-2-chloro-3-fluoropyridine
3-bromo-6-chloro-5-fluoro-pyridine
EN300-113348
C5H2BrClFN
Pyridine, 5-bromo-2-chloro-3-fluoro-
FT-0648094
SY005213
5-BROMO-2-CHLORO-3-FLUORO-PYRIDINE
5-Bromo-2-chloro-3-fluoropyridine, AldrichCPR
AC-4377
3-bromo-6-chloro-5-fluoropyridine
831203-13-5
MFCD03411574
OEKXUEWGXWCENG-UHFFFAOYSA-N
5-bromo-2-chloro-3-fluoro pyridine
AM20061529
5-Bromo-2-chloro-3-fluoropyridin
5-Bromo-2-chloro-3-fluoro-pyridine
5-BROMO-2-CHLORO-3-FLUOROPYRIDINE

MDL Number

MFCD03411574

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Bromo-2-chloro-3-fluoropyridine (CAS: 831203-13-5)?

5-Bromo-2-chloro-3-fluoropyridine (CAS: 831203-13-5) is a crystalline solid with a molecular weight of approximately 246.01 g/mol. It has a low water solubility and is moderately soluble in common organic solvents such as ethanol and acetone. This compound is known for its high reactivity, particularly towards nucleophiles and reducing agents. It is often used in organic synthesis due to its ability to undergo substitution reactions.

How is 5-Bromo-2-chloro-3-fluoropyridine (CAS: 831203-13-5) typically synthesized?

5-Bromo-2-chloro-3-fluoropyridine (CAS: 831203-13-5) is commonly synthesized through a multistep process involving the introduction of bromine, chlorine, and fluorine functionalities onto pyridine. Typical methods include the use of bromination and chlorination of 3-fluoropyridine followed by further functionalization. Catalysts such as fuming sulfuric acid are often employed to control the reaction selectivity and yield.

What industries use 5-Bromo-2-chloro-3-fluoropyridine (CAS: 831203-13-5)?

5-Bromo-2-chloro-3-fluoropyridine (CAS: 831203-13-5) is used in various industries, particularly in pharmaceuticals and materials science. It serves as a key intermediate in the synthesis of more complex molecules and is also used in the development of sensors and semiconductors due to its unique chemical properties and reactivity.

What precautions should be taken when handling 5-Bromo-2-chloro-3-fluoropyridine (CAS: 831203-13-5)?

When handling 5-Bromo-2-chloro-3-fluoropyridine (CAS: 831203-13-5), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or within a fume hood to minimize inhalation risks. Spills should be handled with appropriate absorbent materials and the area should be thoroughly cleaned. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.