4-Fluorobenzamide

Basic Information

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CAS Number

824-75-9

Molecular Formula

C7H6FNO

Molecular Weight

139.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

154.0 to 157.0 deg-C

Boiling Point

253.1℃ at 760 mmHg

Density

1.2099 (estimate)

Flash Point

98.7℃

Refractive Index

1.475

SMILES

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C1=CC(=CC=C1C(=O)N)F

InChI

InChI=1S/C7H6FNO/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H2,9,10)

InChIKey

VNDHYTGVCGVETQ-UHFFFAOYSA-N

LogP

0.9246000000000001

Topological Polar Surface Area

43.09 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

130

Safety Information

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Hazard Statement

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

4-Fluorobenzamide
EINECS 212-535-9
Benzamide, p-fluoro-
4-fluorobenzoamide
DTXSID60231717
W-104173
4fluorobenzamide
4-Fluoro-benzamide
YB79F3XB1G
cid_71572
AKOS001282873
NS00042457
Q27294434
AM20060900
NSC-102765
A840352
MFCD00007992
SCHEMBL52708
p-Fluorobenzamide
F3147-3717
BRN 1859744
BDBM50106200
Z33546459
NSC 102765
W18647
SCHEMBL8259366
F0279
EN300-23709
824-75-9
MLS000060705
4-fluoro benzamide

MDL Number

MFCD00007992

Customs Code

2924299090

FAQ

What are the physical and chemical properties of 4-Fluorobenzamide (CAS: 824-75-9)?

4-Fluorobenzamide (CAS: 824-75-9) is a white crystalline solid with a molecular weight of approximately 146.07 g/mol. It has a melting point of 128-129°C. The compound is slightly soluble in water but more soluble in organic solvents such as ethanol and acetone. It is relatively stable under normal conditions but can react with strong bases to form amine derivatives.

How is 4-Fluorobenzamide (CAS: 824-75-9) typically synthesized?

4-Fluorobenzamide (CAS: 824-75-9) is commonly synthesized via the reaction of 4-fluorobenzoic acid with anhydrous ammonia. This process involves heating the acid with ammonia in the presence of a catalyst like phosphorus oxychloride. The yield is typically around 90%, with good selectivity for the amide formation.

What industries use 4-Fluorobenzamide (CAS: 824-75-9)?

4-Fluorobenzamide (CAS: 824-75-9) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It is also utilized in the polymer industry for the preparation of certain polymer materials. Additionally, it plays a role in the production of sensors and in the semiconductor industry as a precursor for organic materials.

What precautions should be taken when handling 4-Fluorobenzamide (CAS: 824-75-9)?

When handling 4-Fluorobenzamide (CAS: 824-75-9), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a laboratory coat. Ensure that the substance is handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, immediately clean up using appropriate absorbent materials and wash the area with water. Always refer to the safety data sheet (SDS) for detailed information on handling and storage.