1,2-Thiazol-5-amine

Basic Information

View in Editor

CAS Number

82357-92-4

Molecular Formula

C3H4N2S

Molecular Weight

100.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

103.0±23.0 ºC (760 Torr),

Density

1.345±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

16.1±22.6 ºC,

SMILES

View in Editor

C1=C(SN=C1)N

InChI

InChI=1S/C3H4N2S/c4-3-1-2-5-6-3/h1-2H,4H2

InChIKey

GKZNVLJEHYUFIC-UHFFFAOYSA-N

LogP

0.7253000000000001

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

48.1

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SCHEMBL407607
EN300-120928
W16800
82357-92-4
Isothiazol-5-amine
DTXSID80601438
1,2-THIAZOL-5-AMINE
GKZNVLJEHYUFIC-UHFFFAOYSA-N
5-amino-isothiazole
isothiazole-5(2h)-imine
SB38885
5-aminoisothiazole
AKOS006340021
AS-57051
CS-0062263
5-Isothiazolamine(9CI)
Isothiazol-5-ylamine
5-ISOTHIAZOLAMINE
5-Isothiazolamine
1,2-thiazol-5-amine
isothiazol-5-amine hydrochloride

MDL Number

MFCD18821782

FAQ

What are the physical and chemical properties of 1,2-Thiazol-5-amine (CAS: 82357-92-4)?

1,2-Thiazol-5-amine (CAS: 82357-92-4) is a white crystalline solid with a molecular weight of approximately 101.13 g/mol. It has a solubility of about 10.5 mg/mL in water. This compound is moderately reactive, showing basic properties due to the amine group. It is not flammable and does not readily decompose under normal conditions. However, it can react with strong acids to form salts.

How is 1,2-Thiazol-5-amine (CAS: 82357-92-4) typically synthesized?

1,2-Thiazol-5-amine (CAS: 82357-92-4) can be synthesized via the reaction of thiosemicarbazide with hydroxylamine hydrochloride in the presence of an acid catalyst. This process yields the amine in good yield and selectivity. The reaction is typically performed in a solvent such as ethanol or methanol at room temperature.

What industries use 1,2-Thiazol-5-amine (CAS: 82357-92-4)?

1,2-Thiazol-5-amine (CAS: 82357-92-4) is widely used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the production of functional materials, in the sensor industry for its ability to detect certain gases, and in the semiconductor industry for its role in etching processes.

What precautions should be taken when handling 1,2-Thiazol-5-amine (CAS: 82357-92-4)?

When handling 1,2-Thiazol-5-amine (CAS: 82357-92-4), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In case of a spill, neutralize the area with a suitable base and clean up according to standard procedures. Always consult the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.