Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate | CAS No. 82034-46-6

Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

Basic Information

CAS Number

82034-46-6

Molecular Formula

C24H31ClO7

Molecular Weight

466.96 g/mol

AD

Basic Physical Properties

Melting Point

233-237°C

Boiling Point

600.1°C at 760 mmHg

Solubility

DMSO: soluble5mg/mL, clear (warmed)

CCOC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C)C(=O)OCCl

InChI

InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1

InChIKey

DMKSVUSAATWOCU-HROMYWEYSA-N

LogP

3.9165000000000028

Topological Polar Surface Area

99.13000000000001 Ų

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

882

Safety Information

View Safety Information

GHS Hazard Pictograms

H361H361

Hazard Statement

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Synonyms & References

English

  • Loteprednol Etabonate
  • Loteprednol Etabonat
  • (11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-Androsta-1,4-diene-17-carboxylic acid chloromethyl ester
  • CDDD 5604
  • HGP 1
  • P 5604
  • Chloromethyl (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate
  • (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Chloromethyl Ester
  • Chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
  • Lotemax
  • Alrex
  • HGP-1
  • Inveltys
  • YEH1EZ96K6
  • DSSTox_CID_26468
  • DSSTox_RID_81641
  • DSSTox_GSID_46468
  • C24H31ClO7
  • Loterox
  • Locort
  • Lotemax (TN)
  • Lotep
  • chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-((ethoxycarbonyl)oxy)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate

MDL Number

MFCD00870765

FAQ

What is Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 82034-46-6)?

Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 82034-46-6) is a synthetic organic compound with a complex structure. It contains a chloromethyl group and is derived from androsta-1,4-diene, making it relevant in steroid chemistry. This compound is typically characterized by its solubility in organic solvents and its use in pharmaceutical research for potential medicinal applications.

What are the main uses of Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 82034-46-6)?

Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 82034-46-6) is primarily used in pharmaceutical research as a precursor for the synthesis of steroid derivatives. It may also find applications in organic synthesis and drug development, particularly in the creation of compounds with hormonal activity. Its use is generally limited to controlled laboratory environments due to its specialized nature.

Is Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 82034-46-6) safe?

Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 82034-46-6) is considered safe when handled properly in controlled environments. However, due to its chemical complexity, it should be treated with caution. Safety measures include wearing appropriate personal protective equipment (PPE) and following standard laboratory safety protocols. Its toxicity profile is not well-documented, but it is generally regarded as low risk when used as intended.

How should Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 82034-46-6) be stored?

Chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 82034-46-6) should be stored in a cool, dry, and light-protected place. It is best kept in a sealed container at a temperature below 25°C to maintain stability. Avoid exposure to moisture and air to prevent degradation. Proper storage is essential to ensure the compound remains chemically intact and safe for use.

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