1-(1H-Indol-5-yl)methanamine

Basic Information

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CAS Number

81881-74-5

Molecular Formula

C9H10N2

Molecular Weight

146.19 g/mol

Basic Physical Properties

Melting Point

114-122 °C

SMILES

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NCc1ccc2[nH]ccc2c1

InChI

InChI=1S/C9H10N2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-5,11H,6,10H2

InChIKey

UAYYSAPJTRVEQA-UHFFFAOYSA-N

LogP

1.6265999999999998

Topological Polar Surface Area

41.81 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

136

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(1H-Indol-5-yl)methanamine
5-(Aminomethyl)indole
C-(1H-Indol-5-YL)-Methylamine
1-(1H-indol-5-yl)methanamine
1H-indol-5-ylmethanamine
1H-Indol-5-ylmethylamine oxalate
1H-Indole-5-methanamine
indole-5-methylamine
5-aminomethyl indole
5-aminomethyl-1H-indole
indol-5-ylmethylamine
Indole-5-methanamine
INDOLE, 5-(AMINOMETHYL)-
5-aminomethylindole
UAYYSAPJTRVEQA-UHFFFAOYSA-N
1H-Indole-5-methaneamine
1H-Indol-5-ylmethylamine
(1H-indol-5-yl)methylamine
c-(1h-indol-5-yl)methylamine

MDL Number

MFCD01719220

Customs Code

2933990090

FAQ

What regulatory guidelines apply to 1-(1H-Indol-5-yl)methanamine (CAS: 81881-74-5)?

1-(1H-Indol-5-yl)methanamine (CAS: 81881-74-5) is classified under the Globally Harmonized System (GHS) as a Category 3 skin irritant. It is regulated under REACH in the European Union, requiring manufacturers and importers to register substances above 1 tonne per year. The FDA may require pre-market approval for any pharmaceutical applications, while the EPA regulates its use in commercial products to ensure environmental safety.

Are there alternatives to 1-(1H-Indol-5-yl)methanamine (CAS: 81881-74-5) in synthesis?

There are various alternatives to 1-(1H-Indol-5-yl)methanamine (CAS: 81881-74-5) in synthesis, such as indole derivatives like 1-(1H-indol-2-yl)methanamine and 1-(1H-indol-3-yl)methanamine. Common alternative reagents include anilines and substituted anilines, which can be used as precursors or as synthetic intermediates in similar pathways.

What is the market or research trend for 1-(1H-Indol-5-yl)methanamine (CAS: 81881-74-5)?

The market for 1-(1H-Indol-5-yl)methanamine (CAS: 81881-74-5) is driven by its use in pharmaceutical research, particularly for developing potential therapeutic agents. Research trends focus on its biological activity, including its potential as an antidepressant and antiviral compound. The market is expected to grow with more studies confirming its efficacy and safety in clinical applications.

How should waste containing 1-(1H-Indol-5-yl)methanamine (CAS: 81881-74-5) be handled?

Waste containing 1-(1H-Indol-5-yl)methanamine (CAS: 81881-74-5) should be collected in a sealed, leak-proof container and disposed of in accordance with local hazardous waste regulations. Incineration or professional waste disposal services are recommended. Environmental protection measures include proper labeling of waste, minimizing exposure during handling, and following waste minimization strategies to reduce the volume of waste generated.