2-Chloro-4-(trifluoromethyl)pyridine

Basic Information

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CAS Number

81565-18-6

Molecular Formula

C6H3ClF3N

Molecular Weight

181.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Physical State

Liquid

Melting Point

-19°C

Boiling Point

147°C

Density

1.411 g/mL at 25 °C

Flash Point

127 ºF

Refractive Index

n20/D 1.4490(lit.)

SMILES

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C1=CN=C(C=C1C(F)(F)F)Cl

InChI

InChI=1S/C6H3ClF3N/c7-5-3-4(1-2-11-5)6(8,9)10/h1-3H

InChIKey

GBNPVXZNWBWNEN-UHFFFAOYSA-N

LogP

2.753800000000001

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

136

Safety Information

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GHS Hazard Pictograms

H315

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

DTXSID70231203
NS00121540
FT-0611743
C6H3ClF3N
81565-18-6
BCP26619
2-chloro-4-trifluoromethyl-pyridine
PS-6464
2-chloro-4-trifluromethylpyridine
AC-5435
AM20061524
C2568
2-Chloro-4-trifluoromethylpyridine
2-chloro-4-trifluoromethyl pyridine
SCHEMBL119912
Pyridine,2-chloro-4-(trifluoromethyl)
F0001-2099
2-?Chloro-?4-?(trifluoromethyl)?pyridine
EN300-91108
2-Chloro-4-(trifluoromethyl)pyridine
PB28986
2-Chloro-4-(trifluoromethyl)pyridine, 97%
Z1203161839
CS-W008760
2-chloro-4-(trifluoromethyl)-pyridine
MFCD00042224
A9998
Q-101455
AKOS005063345
6-HYDROXY-2-BENZOXAZOLINONE97
Pyridine, 2-chloro-4-(trifluoromethyl)-

MDL Number

MFCD00042224

Customs Code

2933399090

FAQ

What is 2-Chloro-4-(trifluoromethyl)pyridine (CAS: 81565-18-6)?

2-Chloro-4-(trifluoromethyl)pyridine (CAS: 81565-18-6) is an organic compound containing a pyridine ring substituted with a chlorine atom at the 2-position and a trifluoromethyl group at the 4-position. It is a colorless liquid with a pungent odor and is known for its stability under normal conditions. This compound is commonly used as an intermediate in the synthesis of various pharmaceutical and agrochemical products.

What are the main uses of 2-Chloro-4-(trifluoromethyl)pyridine (CAS: 81565-18-6)?

2-Chloro-4-(trifluoromethyl)pyridine (CAS: 81565-18-6) is primarily used in the pharmaceutical industry as a building block for the development of drugs targeting metabolic disorders and neurological conditions. It also finds applications in the synthesis of agrochemicals, specialty chemicals, and as a research reagent for organic synthesis and chemical studies.

Is 2-Chloro-4-(trifluoromethyl)pyridine (CAS: 81565-18-6) safe?

2-Chloro-4-(trifluoromethyl)pyridine (CAS: 81565-18-6) should be handled with care due to its potential toxicity. It is considered harmful if inhaled or ingested, and may cause skin and eye irritation. Safety measures include wearing appropriate personal protective equipment (PPE), ensuring proper ventilation, and following standard laboratory safety protocols for chemical handling.

How should 2-Chloro-4-(trifluoromethyl)pyridine (CAS: 81565-18-6) be stored?

2-Chloro-4-(trifluoromethyl)pyridine (CAS: 81565-18-6) should be stored in a cool, dry, and well-ventilated area away from light. It is best kept in a sealed, airtight container at a temperature below 25°C. Avoid exposure to moisture and incompatible substances to maintain its stability and prevent degradation.