Clarithromycin

Basic Information

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CAS Number

81103-11-9

Molecular Formula

C38H69NO13

Molecular Weight

747.96 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

222.0 to 227.0 deg-C

Boiling Point

805.5°C at 760 mmHg

Density

1.1334 (rough estimate)

Flash Point

>110°(230°F)

Solubility

Soluble in DMSO

Refractive Index

-92 ° (C=1, CHCl3)

Specific Rotation

-85.0° ~ -97.0° (c=1, CHCl3)

SMILES

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CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O

InChI

InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

InChIKey

AGOYDEPGAOXOCK-KCBOHYOISA-N

LogP

2.4397000000000046

Topological Polar Surface Area

182.91 Å²

Hydrogen Bond Donor/Acceptor

4 / 14

Complexity

1190

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Toxicity

LD50 in male, female mice, male, female rats (mg/kg): 2740, 2700, 3470, 2700 orally, 1030, 850, 669, 753 i.p., >5000 all s.c. (Abe)

Synonyms & References

English

Klarid
Clarithromycin identity
CLARITHROMYCIN (USP-RS)
CLARITHROMYCIN [USP-RS]
Clarithromycin 100 microg/mL in Acetonitrile
Klaricid Pediatric
KBio2_003077
Claricide
Clarithromycin for peak identification, European Pharmacopoeia (EP) Reference Standard
AKOS015894242
Klax
CLARITHROMYCIN (USP MONOGRAPH)
D00276
AB00053394-10
HMS3715J17
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
6-O-Methylerythromycin a
PREVPAC COMPONENT CLARITHROMYCIN
KBio2_005645
HMS2051G18
UNII-H1250JIK0A
CLARITHROMYCIN [USP MONOGRAPH]
Clarithromycin, Pharmaceutical Secondary Standard; Certified Reference Material
F14975
BRD-K49668410-001-07-1
Tox21_202903
DTXSID3022829
Zeclar
Clarith
Clathromycin
Clarithromycinum (INN-Latin)