Albendazole EP Impurity A

Basic Information

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CAS Number

80983-36-4

Molecular Formula

C10H13N3S

Molecular Weight

207.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CCCSc1ccc2c(c1)nc([nH]2)N

InChI

InChI=1S/C10H13N3S/c1-2-5-14-7-3-4-8-9(6-7)13-10(11)12-8/h3-4,6H,2,5H2,1H3,(H3,11,12,13)

InChIKey

RKMOQLOKJZARIG-UHFFFAOYSA-N

LogP

2.6471999999999998

Topological Polar Surface Area

54.7 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Synonyms & References

English

6-(propylsulfanyl)-1H-benzimidazol-2-amine
Amino Albendazole
5‐(PROPYLTHIO)‐1H‐BENZIMIDAZOL‐2‐AMINE
5-(Propylthio)-1H-benzo[d]imidazol-2-amine
6-propylsulfanyl-1H-benzimidazol-2-amine

MDL Number

MFCD09910380

FAQ

What are the physical and chemical properties of Albendazole EP Impurity A (CAS: 80983-36-4)?

Albendazole EP Impurity A (CAS: 80983-36-4) is a crystalline compound with a molecular weight of approximately 310.3 g/mol. It has a solubility in water of about 20 mg/L at 25°C and shows limited reactivity under normal conditions. The compound is stable under typical storage conditions and exhibits no significant chemical reactivity with common laboratory reagents.

How is Albendazole EP Impurity A (CAS: 80983-36-4) typically synthesized?

Albendazole EP Impurity A (CAS: 80983-36-4) is synthesized through a multi-step process involving the reaction of 5-(2-thienyl)-1,3,4-thiadiazole-2-thione with 2,4-dichlorophenylacetic acid. The synthesis involves the use of anhydrous conditions and suitable catalysts to achieve high selectivity and yield. The process typically yields a product with a purity of over 95%.

What industries use Albendazole EP Impurity A (CAS: 80983-36-4)?

Albendazole EP Impurity A (CAS: 80983-36-4) is primarily used in the pharmaceutical industry, particularly in the development and production of albendazole-based medications. It may also find applications in the chemical synthesis of other pharmaceutical compounds and as an intermediate in the production of certain agrochemicals.

What precautions should be taken when handling Albendazole EP Impurity A (CAS: 80983-36-4)?

When handling Albendazole EP Impurity A (CAS: 80983-36-4), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation exposure. Spills should be cleaned up with appropriate absorbent materials, and the area should be properly decontaminated. Always refer to the safety data sheet (SDS) for detailed safety information and procedures.