Rifaximin | CAS No. 80621-81-4

Rifaximin

Basic Information

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CAS Number

80621-81-4

Molecular Formula

C43H51N3O11

Molecular Weight

785.9 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

218-228°C

Solubility

ethanol: soluble1mg/mL

SMILES

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CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C

InChI

InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1

InChIKey

NZCRJKRKKOLAOJ-XRCRFVBUSA-N

LogP

6.29580

Complexity

1590

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 orally in rats: >2000 mg/kg (Borelli, Bertoli)

Synonyms & References

English

DB01220
Rifaxidin
Xifaxan
Q416073
HB2568
D02554
HMS3715B19
4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin
Rifaximinum [Latin]
80621-81-4
88747-56-2
AC-19112
RIFAXIMIN [EP MONOGRAPH]
NS00000024
AKOS015963053
alpha-0817185
rifaximinun
Flonorm
Xifaxan (TN)
Fatroximin
Rifamycin L 105SV
AB01209738-01
Rifaximin, Antibiotic for Culture Media Use Only
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
Lumenax
4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV
Q-201671
SCHEMBL124066
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,1
RIFAXIMIN [ORANGE BOOK]
D06AX11

MDL Number

MFCD00864973

FAQ

What is Rifaximin (CAS: 80621-81-4)?

Rifaximin is an antibiotic medication with the CAS number 80621-81-4. It is a semisynthetic rifamycin derivative primarily used for treating gastrointestinal infections. Its chemical formula is C21H26N4O11, and it is known for its broad-spectrum activity against various bacteria. Rifaximin is poorly absorbed from the gastrointestinal tract, making it effective for local treatment in the intestines.

What are the main uses of Rifaximin (CAS: 80621-81-4)?

Rifaximin (CAS: 80621-81-4) is mainly used to treat infections of the gastrointestinal tract, such as traveler's diarrhea caused by enterotoxigenic Escherichia coli. It is also prescribed for hepatic encephalopathy and irritable bowel syndrome with diarrhea. Due to its limited absorption, it is effective in the gut without significant systemic effects, making it a preferred option for localized bacterial infections.

Is Rifaximin (CAS: 80621-81-4) safe?

Rifaximin (CAS: 80621-81-4) is generally considered safe when used as directed. It has a low risk of systemic toxicity and is well-tolerated in most patients. However, like all medications, it may cause side effects such as nausea, headache, or abdominal pain. Proper handling and adherence to medical guidelines are essential to ensure safety and effectiveness.

How should Rifaximin (CAS: 80621-81-4) be stored?

Rifaximin (CAS: 80621-81-4) should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 30°C (59°F to 86°F). The medication should be kept in its original container to protect from moisture and light exposure. Always check the expiration date and ensure storage conditions are appropriate for maintaining stability and potency.