(9cis)-Retinoic acid

Basic Information

View in Editor

CAS Number

8049-47-6

Molecular Formula

C20H28O2

Molecular Weight

300.44 g/mol

EINECS

232-468-9

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Density

1.4-1.52

Water Solubility

Soluble in water. Insoluble in alcohol and ether.

Vapor Pressure

0Pa at 25℃

SMILES

View in Editor

CC1=C(C(CCC1)(C)C)/C=C/C(=C\C=C\C(=C\C(=O)O)\C)/C

InChI

InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+

InChIKey

SHGAZHPCJJPHSC-ZVCIMWCZSA-N

LogP

5.602600000000005

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Safety Information

View Safety Information

GHS Hazard Pictograms

H315

H319

H334

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

-20°C

Stability

Stable. Incompatible with alcohols, strong acids.

Sensitiveness

Sensitive to light

Toxicity

LD50 orl-rat: >10 g/kg YACHDS 3,2427,75

RTECS

RT9033000

Synonyms & References

English

Pancreatin
Pancreatin from Porcine Pancreas (Activity,4xJP)
Pancreatin from porcine pancreas
PANCREATIN, U.S.P. FROM HOG PANCREAS
Diastase vera
N-Phenyl-1-naphthylaMine
Pancrease
Pancreatin, for biocheMistry, powder
Pancreatin, powder, for biochemistry
beefviokase
ilozyme
intrazyme
pancrex-v
pankreon
pankrotanon
panteric
diastasevera
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
(2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraensäure
(9cis)-Retinoic acid
(9cis)-Rétinoïque acide
1UA8E65KDZ
9(Z)-Retinoic acid
9-cis-retinoic acid
9-cis-Tretinoin
9Z-retinoic acid
acide (2E,4E,6Z,8E)-3,7-diméthyl-9-(2,6,6-triméthylcyclohex-1-én-1-yl)nona-2,4,6,8-tétraénoïque
Alitretinoin
alitretinoína
alitrétinoïne
alitretinoinum

MDL Number

MFCD00131789

EC Number

232-468-9

Customs Code

35079090

FAQ

What is (9cis)-Retinoic acid (CAS: 8049-47-6)?

(9cis)-Retinoic acid, with the CAS number 8049-47-6, is a retinoic acid isomer derived from vitamin A. It has the chemical formula C20H28O2 and is a white crystalline powder. This compound is notable for its biological activity and is used in various scientific and medical applications. Its structure features a cis configuration at the 9th carbon, distinguishing it from the more common all-trans retinoic acid.

What are the main uses of (9cis)-Retinoic acid (CAS: 8049-47-6)?

(9cis)-Retinoic acid (CAS: 8049-47-6) is primarily used in pharmaceuticals for dermatological treatments, such as acne and psoriasis, due to its ability to regulate skin cell growth. It also serves as a research tool for studying retinoic acid receptor interactions and is employed in industrial settings as a precursor for other compounds. Its applications are supported by its unique chemical properties and biological activity.

Is (9cis)-Retinoic acid (CAS: 8049-47-6) safe?

(9cis)-Retinoic acid (CAS: 8049-47-6) requires careful handling due to potential toxicity. Prolonged exposure may cause skin irritation or systemic effects, so protective measures like gloves and ventilation are essential. Safety standards emphasize avoiding ingestion, inhalation, or contact with eyes. Proper storage and adherence to guidelines ensure safe use in research and medical contexts.

How should (9cis)-Retinoic acid (CAS: 8049-47-6) be stored?

(9cis)-Retinoic acid (CAS: 8049-47-6) should be stored in airtight, light-resistant containers in a cool, dry place (ideally 2-8°C). It is sensitive to moisture and light, which can degrade its potency. Storage away from heat sources and in a secure location is recommended. Maintaining controlled environmental conditions ensures stability and safety for long-term use.