Fluticasone (propionate)

Basic Information

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CAS Number

80474-14-2

Molecular Formula

C25H31F3O5S

Molecular Weight

500.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Physical State

Powder

Melting Point

275°C

Boiling Point

553.2°C at 760 mmHg

Solubility

DMSO: ≥10 mg/mL

Refractive Index

31 ° (C=1, Dioxane)

Specific Rotation

+29° - +38° (c=1, Dioxane)

SMILES

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CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF

InChI

InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

InChIKey

WMWTYOKRWGGJOA-CENSZEJFSA-N

LogP

4.430000000000004

Topological Polar Surface Area

80.67000000000002 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

984

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DTXSID8045511
BDBM50354849
AB00513992
Fluticasone propionate- Bio-X
Equaline Fluticasone Propionate
Flixonase
Fluticasonpropionat Allen
ADVAIR HFA COMPONENT FLUTICASONE PROPIONATE
YMB56612
Flovent Rotadisk
GTPL7080
HB1091
FLUTICASONE PROPIONATE [EP MONOGRAPH]
Flonase (TN)
O2GMZ0LF5W
FLUTICASONE PROPIONATE [MART.]
80474-14-2
S-Fluoromethyl 6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrost-1,4-diene-17beta-carbothioate
BF161262
Fluticasone propionate for impurity C identification, EuropePharmacopoeia (EP) Reference Standard
FLUTICASONE PROPIONATE [JAN]
NSC 759889
CCI-187881
Fluticasone Propionate Nasal
D01708
FLOVENTHFA
Fluticasone 17(2)-Carbonylsulfenic Acid 17-Propionate
CHILDRENS FLONASE
basic care allergy relief nasal
SCHEMBL4068
KS-1173

MDL Number

MFCD00866007

Customs Code

2937229000

FAQ

What is Fluticasone (propionate) (CAS: 80474-14-2)?

Fluticasone (propionate) is a synthetic corticosteroid medication used for its potent anti-inflammatory and immunosuppressive properties. Its chemical formula is C23H28F2O6, and it is a white to off-white crystalline powder with low solubility in water. It is commonly prescribed for respiratory and skin conditions due to its ability to reduce inflammation and allergic reactions.

What are the main uses of Fluticasone (propionate) (CAS: 80474-14-2)?

Fluticasone (propionate) is primarily used in pharmaceuticals to treat asthma, allergic rhinitis, and eczema. It is also employed in nasal sprays, inhalers, and topical formulations to manage inflammatory diseases. Its applications include reducing airway inflammation, alleviating nasal congestion, and treating skin disorders, making it a key component in respiratory and dermatological therapies.

Is Fluticasone (propionate) (CAS: 80474-14-2) safe?

Fluticasone (propionate) is generally safe when used as directed, but it may cause side effects such as adrenal suppression, local skin reactions, or systemic effects with prolonged use. Handling precautions include wearing gloves and avoiding inhalation. It meets safety standards set by regulatory bodies like the FDA and is classified as a controlled substance in some regions to prevent misuse.

How should Fluticasone (propionate) (CAS: 80474-14-2) be stored?

Fluticasone (propionate) should be stored at room temperature (15-30°C), away from moisture, light, and heat. Keep in airtight containers to maintain stability and prevent degradation. Avoid refrigeration unless specified on the product label, and ensure proper labeling to maintain quality and safety during storage.