2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide

Basic Information

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CAS Number

8032-32-4

Molecular Formula

C6H12F3NOSi

Molecular Weight

199.25 g/mol

EINECS

232-453-7

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Physical State

APHA：≤10

Melting Point

-40℃

Boiling Point

90-100 °C

Density

0.77 g/mL at 20 °C

Water Solubility

Insoluble in water.

Flash Point

−57 °F

Refractive Index

n20/D 1.428

Vapor Pressure

25.8 psi ( 55 °C)

Vapor Density

2.5 (vs air)

Odor

gasoline or kerosene

SMILES

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CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

InChI=1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChIKey

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

LogP

1.8419999999999999

Topological Polar Surface Area

20.310000000000002 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

129

Safety Information

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GHS Hazard Pictograms

H301

H311

H331

H340

H350

H370

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H311 Toxic in contact with skin
Acute toxicity, dermal

H331 Toxic if inhaled
Acute toxicity, inhalation

H340 May cause genetic defects
Germ cell mutagenicity

H350 May cause cancer
Carcinogenicity

H370 Causes damage to organs
Specific target organ toxicity, single exposure

Hazard Class

Class 3 Class 3

Stability

Stable. Highly flammable. Avoid contact with oxidizers and all sources of ignition. Due to its low flash point, this material can ignite when mixed with air upon contact with hot surfaces - no open flame is necessary.

Auto-ignition Temperature

475 °F

Explosive Limit

Toxicity

LD50 intravenous in mouse: 40mg/kg

Synonyms & References

English

Petrol puriss., bp 100-140 C
Petrol puriss., bp 90-100 C
Petroleum (distilled: cut of distillation 100-160 degrees C)
Ligroine Low boiling point naphtha
Petroleum Ether, 30-75 C
Petroleum Ether, 35-60 C
PetroleuM Ether 60-90°
PetroleuM Ether, B.R. 35 DEG -60 DEG C, Reagent, ACS
Petroleum Ether
Benzin
Canadol
Ligroine
naphtha petroleum
naphtha, VM&amp
amp
Petroleum naphtha
Petroleum spirits
Varnish Makers &amp
Painters Naphtha
VM &amp
M NAPHTHA
P Naphtha
Gasoline, premium unleaded
LIGROIN
Benzine (light petroleum distillate)
Naphtha
PetroleuM ether 40
PetroleuM ether 60
PetroleuM spirit
Phosphorus pentoxide

MDL Number

MFCD00081849

EC Number

232-453-7

Customs Code

27101299

FAQ

What is 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (CAS: 8032-32-4)?

2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (CAS: 8032-32-4) is a synthetic organic compound used as a silylating agent. Its chemical formula is C4H8F3NO·Si(CH3)3, featuring a trifluoromethyl group, a methyl group, and a trimethylsilyl group attached to an acetamide backbone. It is a colorless liquid with low reactivity, commonly utilized in protecting amine groups during chemical reactions due to its stability and selectivity.

What are the main uses of 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (CAS: 8032-32-4)?

This compound is widely used in pharmaceutical research for synthesizing complex molecules and modifying functional groups. It serves as a key reagent in organic chemistry for protecting amines, facilitating fluorination reactions, and acting as a nucleophilic silylating agent. Applications also extend to industrial processes and analytical chemistry, where its unique properties aid in molecular manipulation and compound stability.

Is 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (CAS: 8032-32-4) safe?

2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (CAS: 8032-32-4) is generally considered safe when handled properly. It has low toxicity, but precautions include avoiding inhalation, skin contact, and eye exposure. Safety data sheets (SDS) recommend using protective gloves, goggles, and ventilation. It is not classified as highly hazardous, but adherence to standard chemical handling protocols is essential for safe use.

How should 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (CAS: 8032-32-4) be stored?

Store 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (CAS: 8032-32-4) in a sealed, cool, and dry container, away from light and incompatible materials. It remains stable under normal storage conditions but should be kept at temperatures below 25°C. Avoid exposure to moisture and ensure proper ventilation to maintain its integrity and safety.