Homatropine methylbromide

Basic Information

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CAS Number

80-49-9

Molecular Formula

C17H24BrNO3

Molecular Weight

370.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

193.0 to 198.0 deg-C

Boiling Point

403.3±45.0 °C at 760 mmHg

Density

1.2±0.1 g/cm3

Flash Point

197.7±28.7 °C

Refractive Index

1.588

Vapor Pressure

0.0±1.0 mmHg at 25°C

SMILES

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C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]

InChI

InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15?,16?;

InChIKey

FUFVKLQESJNNAN-ZZJGABIISA-M

LogP

-1.00420

Complexity

374

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede)

Synonyms & References

English

Homatropini methylbromidum [INN-Latin]
Mesopin
HOMATROPINE METHYLBROMIDE [USP MONOGRAPH]
CCG-268291
H0448
Novatrine
8-Azoniabicyclo(3.2.1)octane, 3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromide, (3-endo)-
Homapin-10
homatropine methylbromide
Novatropine
HOMATROPINE METHYLBROMIDE [MART.]
UNII-68JRS2HC1C
8-Azoniabicyclo(3.2.1)octane, 3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromide, endo-
Arkitropin
D02070
HMS3652C19
68JRS2HC1C
Metilbromuro de homatropina
NSC-757048
CHEMBL1200851
Q2605497
HOMATROPINE METHYLBROMIDE [ORANGE BOOK]
HOMATROPINE METHYLBROMIDE [MI]
8-Azoniabicyclo[3.2.1]octane, 3-[(hydroxyphenylacetyl)oxy]-8,8-dimethyl-, bromide, endo-(.+-.)-
HYDROPANE COMPONENT HOMATROPINE METHYLBROMIDE
Malcotran
Esopin
HOMATROPINE METHYLBROMIDE [WHO-DD]
Methylbromure d'homatropine [INN-French]
Methylhomatropinum bromatum
Homatropine methylbromide [BAN:INN]

MDL Number

MFCD00050292

FAQ

What is Homatropine methylbromide (CAS: 80-49-9)?

Homatropine methylbromide (CAS: 80-49-9) is a quaternary ammonium compound used primarily as an anticholinergic medication. It has a molecular formula of C14H22BrNO2. This compound is known for its ocular effects and is used in eye drops for mydriasis and cycloplegia.

What are the main uses of Homatropine methylbromide (CAS: 80-49-9)?

Homatropine methylbromide (CAS: 80-49-9) is mainly used in ophthalmology as an anticholinergic agent. It is applied topically in eye drops to dilate the pupils and paralyze accommodation (cycloplegia) during eye examinations and surgeries. It is also used for therapeutic purposes in refractive surgery and ophthalmic diagnostic procedures.

Is Homatropine methylbromide (CAS: 80-49-9) safe?

Homatropine methylbromide (CAS: 80-49-9) is generally considered safe when used as directed. However, it can cause side effects such as dry mouth, blurred vision, and increased heart rate. It is important to follow medical guidance and avoid contact with eyes and other mucous membranes. Protective measures include wearing gloves and using appropriate personal protective equipment.

How should Homatropine methylbromide (CAS: 80-49-9) be stored?

Homatropine methylbromide (CAS: 80-49-9) should be stored in a tightly sealed container to protect it from moisture and light. Store at room temperature, avoiding extreme temperatures. Keep out of reach of children and ensure that the storage area is well-ventilated. Do not expose to direct sunlight or high humidity. Proper storage helps maintain the stability and effectiveness of the compound.