Azelastine HCl

Basic Information

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CAS Number

79307-93-0

Molecular Formula

C22H25Cl2N3O

Molecular Weight

418.37 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

224.0 to 228.0 deg-C

Solubility

DMSO: >10mg/mL

SMILES

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CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl

InChI

InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H

InChIKey

YEJAJYAHJQIWNU-UHFFFAOYSA-N

LogP

4.719300000000004

Topological Polar Surface Area

38.13 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

558

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Stability

Incompatible with strong oxidizing agents.

Sensitiveness

thermally sensitive

Toxicity

LD50 in male, female mice, male, female rats (mg/kg): 36.5, 35.5, 26.9, 30.3 i.v.; 56.4, 42.8, 43.2, 46.6 i.p.; 63.0, 54.2, 66.5, 59.6 s.c.; 124, 139, 310, 417 orally (Zechel)

Synonyms & References

English

BCP9000369
AZELASTINE HYDROCHLORIDE (USP-RS)
SR-01000762975-4
SW197471-3
Radethazin
Tox21_111469_1
AZELASTINE HYDROCHLORIDE (MART.)
NSC758971
W- 979M
NCGC00177979-05
Azelastine hydrochloride, United States Pharmacopeia (USP) Reference Standard
Azelastine HCl Nasal
Astelin (TN)
4-((4-Chlorophenyl)methyl)-2-((4RS)-(1-methylazepan-4-yl))phthalazin-1(2H)-one monohydrochloride
SR-01000762975
E-0659
(S)-4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
DYMISTA COMPONENT AZELASTINE HYDROCHLORIDE
CAS-79307-93-0
Azelastine Hydrochloride Ophthalmic Solution 0.05%
Children Astepro Allergy
CCG-100841
Azelastine (hydrochloride)
W-979M
CPD000469183
ASTEPRO ALLERGY
D00659
Azelastine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one hydrochloride
Azelastine hydrochloride (Astelin)
AZELASTINE HYDROCHLORIDE [WHO-DD]

MDL Number

MFCD00242783

FAQ

What is Azelastine HCl (CAS: 79307-93-0)?

Azelastine HCl (CAS: 79307-93-0) is an antihistamine medication used primarily for treating allergic conditions. It is a hydrochloride salt of azelastine, a compound with the chemical formula C13H20N4O2. It is known for its ability to block histamine receptors, reducing symptoms such as sneezing, itching, and runny nose. Azelastine HCl is commonly found in nasal sprays and eye drops.

What are the main uses of Azelastine HCl (CAS: 79307-93-0)?

Azelastine HCl (CAS: 79307-93-0) is mainly used in pharmaceuticals to treat allergic rhinitis, conjunctivitis, and other allergic reactions. It is also used in topical formulations for nasal and ocular applications. In research, it serves as a tool for studying histamine receptor antagonism and its effects on inflammatory responses.

Is Azelastine HCl (CAS: 79307-93-0) safe?

Azelastine HCl (CAS: 79307-93-0) is generally considered safe when used as directed. However, it may cause side effects such as drowsiness, dry mouth, and headache. Proper handling is essential, especially in industrial settings, to avoid skin or eye contact. Safety standards for its use are well-established in medical and pharmaceutical contexts.

How should Azelastine HCl (CAS: 79307-93-0) be stored?

Azelastine HCl (CAS: 79307-93-0) should be stored in a cool, dry place away from direct light. It is typically kept in airtight containers to maintain stability and prevent degradation. Storage conditions should be between 15°C to 25°C (59°F to 77°F) with low humidity to ensure product integrity and effectiveness.