Ceftazidime pentahydrate

Basic Information

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CAS Number

78439-06-2

Molecular Formula

C22H32N6O12S2

Molecular Weight

425.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

196°C

Solubility

Sparingly soluble in aqueous solution

SMILES

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CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-].O.O.O.O.O

InChI

InChI=1S/C16H19N5O5S2/c1-7-4-21-12(23)10(13(21)27-5-7)19-11(22)9(8-6-28-15(17)18-8)20-26-16(2,3)14(24)25/h4,6,10,13H,5H2,1-3H3,(H2,17,18)(H,19,22)(H,24,25)/t10-,13-/m1/s1

InChIKey

ITQRSTUCWZVUCT-ZWNOBZJWSA-N

LogP

0.6128999999999991

Topological Polar Surface Area

147.21 Å²

Hydrogen Bond Donor/Acceptor

4 / 10

Complexity

1020

Safety Information

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Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

Synonyms & References

English

AC-18971
NS00076156
78439-06-2
Ceftazidime pentahydrate
CCG-270303
(Z)-(7R)-7-[2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-(1-pyridiniomethyl)-3-cephem-4-carboxylate pentahydrate
Ceftazidime (pentahydrate)
GR20263 (pentahydrate)
HMS1569B19
AKOS015962877
MFCD00153936
Ceftazidime Pentahydrate(Contain 1 equivalent of Na2CO3 as stabilizer)
GR20263
(6R,7R)-7-[[(2E)-2-(2-Amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrate
Ceftazidime
1-[[(6r,7r)-7-[[(2z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl]methyl]pyridinum hydroxide inner salt
1-[[(6R,7R)-7-[[(2Z)-(2-AMINO-4-THIAZOLYL)[(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL]AMINO]-2-CARBOXY-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-EN-3-YL]METHYL]PYRIDINUM PENTAHYDRATE
CEFTAZIDIME PENTAHYDRATE
cazpentahydrate
gr20263pentahydrate
innersalt,(6r-(6-alpha,7-beta(z)))-droxidpentahydrate
sn401pentahydrate
CEFTAZIME
Ceftazidime Pentahydrate (Contain 1 equivalent of Na2CO3 as stabilizer)
Ceftazidime (hydrate)
Ceftazidime Pentahydrate (Contain 1 equivalent of Na2CO3 as stabilizer)
(6R,7R)-7-({(2E)-2-(2-amino-1,3-thiazol-4-y
(6R,7R)-7-({(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl}amino)-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate pentahydrate
pentahydrate (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

MDL Number

MFCD00153936

Customs Code

29419000

FAQ

What regulatory guidelines apply to Ceftazidime pentahydrate (CAS: 78439-06-2)?

Ceftazidime pentahydrate (CAS: 78439-06-2) is subject to various regulatory guidelines depending on its intended use. For pharmaceutical applications, it must adhere to FDA, EPA, and WHO standards. In the EU, it is also regulated by REACH for safety and environmental concerns. Manufacturers must ensure compliance with the specific regulatory requirements of the region in which the product is sold.

Are there alternatives to Ceftazidime pentahydrate (CAS: 78439-06-2) in synthesis?

There are several alternatives to Ceftazidime pentahydrate (CAS: 78439-06-2) in synthesis, such as other third-generation cephalosporins. These alternatives include ceftriaxone and cefotaxime, which are often used as substitutes due to their similar antimicrobial activity. Other synthetic routes may involve the use of different precursors or reagents to achieve similar outcomes.

What is the market or research trend for Ceftazidime pentahydrate (CAS: 78439-06-2)?

The market for Ceftazidime pentahydrate (CAS: 78439-06-2) is driven by its critical role in the treatment of serious bacterial infections. Recent research trends focus on understanding its mechanism of action and exploring its potential in combination therapies. The demand is also influenced by the increasing prevalence of antibiotic-resistant bacteria, driving the need for effective alternatives.

How should waste containing Ceftazidime pentahydrate (CAS: 78439-06-2) be handled?

Waste containing Ceftazidime pentahydrate (CAS: 78439-06-2) should be handled with care due to its pharmaceutical nature. It should be collected in designated containers and disposed of according to local regulations. Incineration is a common method, but professional waste disposal services are recommended. Environmental protection measures should be followed to prevent contamination of water and soil.