2-(4-Morpholinyl)-5-(trifluoromethyl)aniline

Basic Information

View in Editor

CAS Number

784-57-6

Molecular Formula

C11H13F3N2O

Molecular Weight

246.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

127-128°C

Boiling Point

348.5 ºC at 760 mmHg

Density

1.306

Water Solubility

Insoluble in water.

Flash Point

164.6 ºC

Refractive Index

1.519

SMILES

View in Editor

C1COCCN1C2=C(C=C(C=C2)C(F)(F)F)N

InChI

InChI=1S/C11H13F3N2O/c12-11(13,14)8-1-2-10(9(15)7-8)16-3-5-17-6-4-16/h1-2,7H,3-6,15H2

InChIKey

CNVOJNRNRNAOOP-UHFFFAOYSA-N

LogP

2.1242

Topological Polar Surface Area

38.489999999999995 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

254

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H331 Toxic if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

2-(4-morpholinyl)-5-(trifluoromethyl)aniline
EN300-02435
Enamine_001060
HMS1397A04
2-(4-morpholinyl)-5-(trifluoromethyl)phenylamine
SR-01000029028
F3111-1182
CS-0157123
2-morpholino-5-trifluoromethylaniline
SCHEMBL330446
DTXSID10229063
MLS001007011
N-(2-Amino-4-(trifluoromethyl)phenyl)morpholine
PS-11122
2-Morpholin-4-yl-5-trifluoromethyl-phenylamin e
BB 0245673
A839428
2-morpholin-4-yl-5-(trifluoromethyl)aniline
Benzenamine,2-(4-morpholinyl)-5-(trifluoromethyl)-
MFCD00042160
SMR000349801
784-57-6
FT-0629617
2-Morpholin-4-yl-5-trifluoromethyl-phenylamine
n-[2-amino-4-(trifluoromethyl)phenyl]-morpholine
3-amino-4-(4-morpholino)benzotrifluoride
4-(2-amino-4-trifluoromethylphenyl)morpholine
SDCCGMLS-0065839.P001
AS-871/41682772
SY062164
HMS2733D10

MDL Number

MFCD00042160

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-(4-Morpholinyl)-5-(trifluoromethyl)aniline (CAS: 784-57-6)?

2-(4-Morpholinyl)-5-(trifluoromethyl)aniline (CAS: 784-57-6) is a white crystalline solid with a molecular weight of approximately 311.17 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and dichloromethane. This compound is known for its low reactivity, making it suitable for various applications. Its hydrophobic nature and high electron-withdrawing capability from the trifluoromethyl group make it useful in organic synthesis and pharmaceuticals.

How is 2-(4-Morpholinyl)-5-(trifluoromethyl)aniline (CAS: 784-57-6) typically synthesized?

2-(4-Morpholinyl)-5-(trifluoromethyl)aniline (CAS: 784-57-6) is commonly synthesized via the Friedel-Crafts alkylation of 4-morpholinylaniline with trifluoromethylating agents like trifluoromethyl sulfonyl chloride in the presence of a Lewis acid catalyst. The reaction yields a high selectivity and good yield, making it a reliable method for industrial production. Detailed procedures are available in the literature and textbooks.

What industries use 2-(4-Morpholinyl)-5-(trifluoromethyl)aniline (CAS: 784-57-6)?

2-(4-Morpholinyl)-5-(trifluoromethyl)aniline (CAS: 784-57-6) finds application in pharmaceuticals, where it serves as a precursor for drug synthesis, and in polymer science, where its electronic properties are utilized. It is also used in the production of sensors and semiconductors, leveraging its unique chemical and physical properties.

What precautions should be taken when handling 2-(4-Morpholinyl)-5-(trifluoromethyl)aniline (CAS: 784-57-6)?

When handling 2-(4-Morpholinyl)-5-(trifluoromethyl)aniline (CAS: 784-57-6), it is important to wear protective equipment such as gloves, goggles, and a lab coat to protect against skin and eye contact. Store the compound under a fume hood to avoid inhalation. In case of spill, immediately clean up with caution, ensuring proper disposal of waste. Always refer to the Safety Data Sheet (SDS) for detailed safety guidelines and emergency procedures.