2-Methyl-1-propanamine

Basic Information

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CAS Number

78-81-9

Molecular Formula

C4H11N

Molecular Weight

73.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

−85 °C

Boiling Point

64-71 °C

Density

0.736 g/mL at 25 °C

Solubility

1000g/l

Refractive Index

n20/D 1.397(lit.)

SMILES

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CC(C)CN

InChI

InChI=1S/C4H11N/c1-4(2)3-5/h4H,3,5H2,1-2H3

InChIKey

KDSNLYIMUZNERS-UHFFFAOYSA-N

LogP

0.6011000000000001

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

17.6

Safety Information

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GHS Hazard Pictograms

H225

H301

H314

Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H301 Toxic if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 3 Class 3

Explosive Limit

2-9%(V)

Toxicity

LD50 (14 day) in male, female rats (mg/kg): 224.4, 231.8 orally (Cheever)

Synonyms & References

English

Isobutylamine
1-Amino-2-methylpropane
2-methyl-1-propanamine
2-Methylpropanamine
2-methylpropylamine
monoisobutylamine
valamine
1-AMinoisobutane
1-Propanamine, 2-methyl-
2-Methyl propylaMine
2-Methyl-1-Aminopropane
3-Methyl-2-propylamine
i-Butylamine
iso-C4H9NH2
NSC 8028
UN 1214
2-Methyl-1-propanamine
2-methylpropan-1-amine

MDL Number

MFCD00008146

FAQ

What are the physical and chemical properties of 2-Methyl-1-propanamine (CAS: 78-81-9)?

2-Methyl-1-propanamine is a colorless, flammable liquid with a pungent odor. Its molecular weight is 83.13 g/mol. It is soluble in water and has good solubility in organic solvents. Chemically, it is mildly basic and reactive towards carboxylic acids and acid chlorides. It is not highly corrosive but requires handling with care due to its flammability and irritancy.

How is 2-Methyl-1-propanamine (CAS: 78-81-9) typically synthesized?

2-Methyl-1-propanamine is usually synthesized via the reduction of 2-methyl-1-propanone with a reducing agent like lithium aluminum hydride (LAH) or sodium borohydride. The process involves a mild hydrogenation step, yielding a high yield of the amine with good selectivity. The reaction is typically conducted in anhydrous solvents like ether to ensure optimal conditions.

What industries use 2-Methyl-1-propanamine (CAS: 78-81-9)?

2-Methyl-1-propanamine finds applications in the pharmaceutical industry for the synthesis of certain drugs, as well as in the polymer industry where it serves as a monomer for the production of polyamides. It is also utilized in the production of sensors and semiconductors due to its unique reactivity and solubility properties.

What precautions should be taken when handling 2-Methyl-1-propanamine (CAS: 78-81-9)?

When handling 2-Methyl-1-propanamine, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat is essential. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation risks. Spills should be managed carefully using appropriate absorbents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.