Doxazosin Mesylate

Basic Information

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CAS Number

77883-43-3

Molecular Formula

C24H29N5O8S

Molecular Weight

547.6 g/mol

Basic Physical Properties

Melting Point

248-255°C

Boiling Point

718°C at 760 mmHg

Density

1.371

Flash Point

No data available

Vapor Pressure

No data available

SMILES

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COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.CS(=O)(=O)O

InChI

InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)

InChIKey

VJECBOKJABCYMF-UHFFFAOYSA-N

LogP

1.2218000000000007

Topological Polar Surface Area

166.64 Å²

Hydrogen Bond Donor/Acceptor

3 / 13

Complexity

770

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Protect from light

Synonyms & References

English

(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone methanesulfonate
NS00076336
DOXAZOSIN MESILATE [MART.]
NSC 759284
Doxazosin mesylate, United States Pharmacopeia (USP) Reference Standard
Cardura (TN)
Cardular Uro
D4126
Doxaben
86P6PQK0MU
MLS001148153
Doxolbran
Doxazosin mesilate
DOXAZOSIN MESYLATE [HSDB]
UK-33,274-27
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[4-(1,4-benzodioxan-2-yl)carpiperazin-1-yl)]-6,7-dimethoxyquinazoline mesylate
MFCD00216023
Prestwick_1026
NCGC00018158-09
A839262
SR-01000003045-8
2-{4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid
Diblocin Uro
Doxazosin mesylate [USAN:USP]
DOXAZOSIN MESYLATE [ORANGE BOOK]
Normathen
SR-01000003045-2
doxazosin mesylate salt
Doxazosin (mesylate)
Tox21_500474
D 9815

MDL Number

MFCD00216023

FAQ

What is Doxazosin Mesylate (CAS: 77883-43-3)?

Doxazosin Mesylate (CAS: 77883-43-3) is a synthetic compound used as a prodrug for Doxazosin, an alpha-1 adrenergic receptor antagonist. Its chemical formula is C19H23N3O4S, and it appears as a white crystalline powder. It is highly soluble in water and has a molecular weight of 393.46 g/mol. This compound is primarily employed in pharmaceutical applications for its therapeutic effects in treating hypertension and benign prostatic hyperplasia.

What are the main uses of Doxazosin Mesylate (CAS: 77883-43-3)?

Doxazosin Mesylate (CAS: 77883-43-3) is mainly used in pharmaceuticals to treat hypertension (high blood pressure) and benign prostatic hyperplasia (BPH). It works by relaxing blood vessels and reducing fluid retention. Additionally, it serves as a research tool for studying alpha-1 blocker mechanisms. Its applications are well-documented in medical literature, making it a key compound in cardiovascular and urological treatments.

Is Doxazosin Mesylate (CAS: 77883-43-3) safe?

Doxazosin Mesylate (CAS: 77883-43-3) is safe when used as directed by healthcare professionals. It has a favorable safety profile in therapeutic doses but may cause side effects like dizziness, fainting, or hypotension. Proper handling is essential, especially in research settings, to avoid skin contact or inhalation. Safety standards require adherence to regulatory guidelines for storage and disposal to ensure minimal risk.

How should Doxazosin Mesylate (CAS: 77883-43-3) be stored?

Doxazosin Mesylate (CAS: 77883-43-3) should be stored in a cool, dry place (15-30°C), away from direct light. Maintain low humidity levels and use airtight containers to preserve stability. It is recommended to store the compound in a secure location to prevent unauthorized access, as it is a controlled substance. Proper storage ensures optimal shelf life and safety during handling.