N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide | CAS No. 778277-15-9

N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide

Basic Information

CAS Number

778277-15-9

Molecular Formula

C20H17F3N4O3

Molecular Weight

418.38 g/mol

AD

Basic Physical Properties

Solubility

DMSO: soluble10mg/mL (clear solution)

C1=CC(=CC(=C1)C(=O)NCCO)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F

InChI

InChI=1S/C20H17F3N4O3/c21-20(22,23)30-16-6-4-15(5-7-16)27-18-11-17(25-12-26-18)13-2-1-3-14(10-13)19(29)24-8-9-28/h1-7,10-12,28H,8-9H2,(H,24,29)(H,25,26,27)

InChIKey

IIQUYGWWHIHOCF-UHFFFAOYSA-N

LogP

3.507900000000002

Topological Polar Surface Area

96.37 Ų

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

544

Safety Information

View Safety Information

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral
H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

  • GNF 5
  • HY-15738
  • s7526
  • EX-A312
  • HMS3653H13
  • EN300-251361
  • CHEMBL1257423
  • N-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide
  • N-(2-hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
  • CCG-268867
  • Benzamide, N-(2-hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)-4-pyrimidinyl)-
  • SMR001913506
  • HMS3744C21
  • GNF5
  • N-(2-hydroxyethyl)-3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide
  • FT-0700364
  • BS-17616
  • UNII-3ZUA56XMQQ
  • AC-32986
  • Bcr-abl Inhibitor III
  • 3ZUA56XMQQ
  • BCP08970
  • N-(2-hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)benzamide
  • SW219191-1
  • GNF-5, >=98% (HPLC)
  • GTPL8065
  • SCHEMBL924071
  • NCGC00351432-08
  • Q27077826
  • GNF-5
  • Abl Inhibitor III

MDL Number

MFCD16877246

FAQ

What is N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778277-15-9)?

N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778277-15-9) is a chemical compound with a complex structure, featuring a benzamide group, a hydroxyl group, and a pyrimidine ring. It is water-soluble and has a melting point of approximately 190°C. This compound is used in pharmaceutical applications for its potential biological activity.

What are the main uses of N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778277-15-9)?

N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778277-15-9) is primarily used in pharmaceutical research and development for its potential therapeutic effects. It can be utilized as a precursor or intermediate in the synthesis of other organic compounds with specific biological activities.

Is N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778277-15-9) safe?

N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778277-15-9) is generally considered safe when handled under proper conditions. However, it is important to follow safety guidelines, such as wearing personal protective equipment (PPE) and avoiding contact with skin and eyes. Storage in a cool, dry place away from direct sunlight is recommended.

How should N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778277-15-9) be stored?

N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778277-15-9) should be stored in a tightly sealed container in a cool, dry place, preferably below 25°C, and away from direct sunlight. It is important to keep it away from heat sources and to handle it under appropriate laboratory conditions to ensure safety and stability.

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