Ataluren | CAS No. 775304-57-9

Ataluren

Basic Information

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CAS Number

775304-57-9

Molecular Formula

C15H9FN2O3

Molecular Weight

284.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

242 °C

Boiling Point

503.7°C at 760 mmHg

Density

1.379

SMILES

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C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F

InChI

InChI=1S/C15H9FN2O3/c16-12-7-2-1-6-11(12)14-17-13(18-21-14)9-4-3-5-10(8-9)15(19)20/h1-8H,(H,19,20)

InChIKey

OOUGLTULBSNHNF-UHFFFAOYSA-N

LogP

3.2409000000000017

Topological Polar Surface Area

76.22 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

382

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Ataluren (PTC124)
NCGC00168759
PTC124;3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid;PTC-124
BDBM50582214
SB16685
CHEMBL256997
FT-0651455
JBF
MLS006011160
NCGC00168759-02
PTC124
PTC 124
PTC124,Ataluren
MFCD09864996
BCPP000097
BB 0261439
DTXCID3026776
AU-004/43508117
Translarna
ATALUREN [WHO-DD]
AKOS005146455
EN300-7386374
Ataluren; PTC124
SCHEMBL60614
NCGC00168759-05
OOUGLTULBSNHNF-UHFFFAOYSA-N
Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-
Ataluren [USAN:INN]
DB05016
D09323
PTC-124

MDL Number

MFCD09864996

Customs Code

2934999090

FAQ

What is Ataluren (CAS: 775304-57-9)?

Ataluren, also known as PTC124, is a chemical compound used in the treatment of Duchenne muscular dystrophy due to a nonsense mutation. Its chemical formula is C13H17N3O3. Ataluren is a non-nucleoside trans-acting factor that binds to the nonsense codons in mRNA, allowing for the translation of the full-length protein.

What are the main uses of Ataluren (CAS: 775304-57-9)?

Ataluren is primarily used in the treatment of Duchenne muscular dystrophy (DMD) associated with a nonsense mutation. It helps in the production of full-length dystrophin protein by binding to premature stop codons in the mRNA, thereby promoting the production of functional dystrophin.

Is Ataluren (CAS: 775304-57-9) safe?

Ataluren has been evaluated for safety in clinical trials. It is generally well-tolerated, with the most common side effects being headache, dizziness, and nausea. However, it is important to follow safety guidelines, including conducting regular health check-ups and monitoring for any adverse reactions. Always store the compound in a secure location, away from children and pets.

How should Ataluren (CAS: 775304-57-9) be stored?

Ataluren should be stored in a cool, dry place, away from direct sunlight and moisture. It is recommended to keep the compound in its original container to protect it from contamination. Ensure that the storage area is well-ventilated and maintain a temperature between 15°C and 25°C. Always check the expiration date and discard any unused portions that have passed the expiration date.