(3R)-3-Hydroxy-2-pyrrolidinone

Basic Information

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CAS Number

77510-50-0

Molecular Formula

C4H7NO2

Molecular Weight

101.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

100-103 ºC

Boiling Point

364 ºC

Density

1.292

Flash Point

174 ºC

Refractive Index

1.513

SMILES

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C1CNC(=O)C1O

InChI

InChI=1S/C4H7NO2/c6-3-1-2-5-4(3)7/h3,6H,1-2H2,(H,5,7)/t3-/m1/s1

InChIKey

FRKGSNOMLIYPSH-GSVOUGTGSA-N

LogP

-1.1328

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

91.7

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

FRKGSNOMLIYPSH-GSVOUGTGSA-N
AMY14450
(R)-(+)-3-hydroxy-2-pyrrolidinone
(R)-3-hydroxy-pyrrolidin-2-one
AKOS016842412
EN300-93559
CS-W018663
MFCD12911759
(3R)-3-Hydroxy-2-Pyrrolidinone
RKL10137
Q-103494
77510-50-0
(3R)-3-hydroxypyrrolidin-2-one
(R)- 3-HYDROXY-2-PYRROLIDINONE
DTXSID50348929
SCHEMBL321868
(R)-3-Hydroxy-2-pyrrolidone
DS-13015
(R)-3-Hydroxypyrrolidin-2-one
(3R)-3-hydroxy-2-pyrrolidinone
(R)-4-hydroxy-2-oxopyrrolidine
2-pyrrolidinone,3-hydroxy
2-Oxopyrrolidine-3alpha-ol
CH0019
FCH951513
RP18726
AB0026687
AX8162579
W84

MDL Number

MFCD12911759

FAQ

What regulatory guidelines apply to (3R)-3-Hydroxy-2-pyrrolidinone (CAS: 77510-50-0)?

The regulatory guidelines applicable to (3R)-3-Hydroxy-2-pyrrolidinone (CAS 77510-50-0) include the European Union's REACH regulations, which require manufacturers and importers to register substances if they are manufactured or imported in quantities greater than one ton per year. Additionally, the chemical is listed as a hazardous substance under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), requiring specific hazard communication. The U.S. EPA also regulates this compound under the Toxic Substances Control Act (TSCA) and may require reporting if used in certain quantities.

Are there alternatives to (3R)-3-Hydroxy-2-pyrrolidinone (CAS: 77510-50-0) in synthesis?

Yes, there are alternatives to (3R)-3-Hydroxy-2-pyrrolidinone (CAS 77510-50-0) in synthesis, such as other cyclic amides like γ-butyrolactone or ε-caprolactam. These alternatives can be used as precursors or intermediates in similar chemical reactions, offering similar functionality with different properties. The choice of alternative depends on the specific requirements of the synthesis, such as reactivity, solubility, and cost.

What is the market or research trend for (3R)-3-Hydroxy-2-pyrrolidinone (CAS: 77510-50-0)?

The market for (3R)-3-Hydroxy-2-pyrrolidinone (CAS 77510-50-0) is growing due to its applications in pharmaceuticals, cosmetics, and as a reagent in organic synthesis. Research trends focus on exploring its use as a green solvent and in developing new synthetic methods. Additionally, there is increasing interest in understanding its biological properties and potential health effects, which may influence future market dynamics and regulatory requirements.

How should waste containing (3R)-3-Hydroxy-2-pyrrolidinone (CAS: 77510-50-0) be handled?

Waste containing (3R)-3-Hydroxy-2-pyrrolidinone (CAS 77510-50-0) should be collected and disposed of according to local and international regulations. Proper waste management includes segregating the waste and ensuring it is handled by a licensed hazardous waste disposal company. Incineration is a common method for disposal, but other options like chemical treatment or biodegradation may be considered depending on the local waste management practices and the chemical's properties. Always follow the guidelines provided by REACH and local environmental agencies to ensure compliance and protect the environment.