N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine

Basic Information

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CAS Number

77128-70-2

Molecular Formula

C18H17NO4

Molecular Weight

311.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

117.0 to 121.0 deg-C

Boiling Point

512.8°C at 760 mmHg

Solubility

Soluble in DMF.

SMILES

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CN(CC(=O)O)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C18H17NO4/c1-19(10-17(20)21)18(22)23-11-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,16H,10-11H2,1H3,(H,20,21)

InChIKey

ZHKQIADIIYMFOZ-UHFFFAOYSA-N

LogP

2.951900000000001

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

430

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

A838964
2-(9H-fluoren-9-ylmethoxycarbonyl-methylamino)acetic acid
DS-9904
SY021181
Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-
Fmoc-sarcosine
n-[(9h-fluoren-9-ylmethoxy)carbonyl]-n-methylglycine
Fmoc-Nalpha-methylglycine
[(9h-fluoren-9-ylmethoxycarbonyl)methylamino]acetic acid
nalpha-(9-fluorenylmethoxycarbonyl)-sarcosine
CS-W012058
HY-W011342
ZHKQIADIIYMFOZ-UHFFFAOYSA-N
Fmoc-N-methylglycine
2-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}(METHYL)AMINO)ACETIC ACID
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)acetic acid
n-fmoc-n-methylglycine
MFCD00151926
Fmoc-Sar-OH, >=98.0%
fmoc-n-me-gly-oh
Q-101727
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methylglycine
N-Alpha-(9-Fluorenylmethyloxycarbonyl)-N-Alpha-Methyl-Glycine
FT-0641635
n-alpha-(9-fluorenylmethyloxycarbonyl)-sarcosine
[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetic acid Fmoc-Sar-OH
Fmoc-Sar-OH. H2O
F1163
Fmoc-Sar-OH
Z1123720000
AKOS009157239

MDL Number

MFCD00151926

Customs Code

2922509090

FAQ

What are the physical and chemical properties of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine (CAS: 77128-70-2)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine is a white crystalline solid with a molecular weight of approximately 432.45 g/mol. It is sparingly soluble in water but more soluble in organic solvents like DMSO and ethanol. This compound is reactive and susceptible to hydrolysis, making it important to store in a dry, cool place and avoid prolonged exposure to moisture or heat.

How is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine (CAS: 77128-70-2) typically synthesized?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine can be synthesized via multi-step organic synthesis involving coupling of fluorenylmethoxycarbonyl chloride (Fmoc-Cl) with N-methylglycine. Commonly, this process involves the formation of an intermediate which is then reacted to yield the final compound. The synthesis typically requires the use of appropriate solvents and catalysts to ensure high yield and selectivity.

What industries use N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine (CAS: 77128-70-2)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine is primarily used in the pharmaceutical industry for the preparation of various drugs. It is also used in the polymer industry for the synthesis of functional polymers, and in the semiconductor industry for the production of certain organic electronic materials. Additionally, it finds applications in the development of chemical sensors due to its specific reactivity and functional groups.

What precautions should be taken when handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine (CAS: 77128-70-2)?

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coat. Ensure the use of a fume hood during preparation and storage to avoid exposure to vapors. In case of a spill, immediately clean up using appropriate absorbent material and follow the safety data sheet (SDS) for further guidance. This compound is reactive and should be stored in a dry, cool place to prevent hydrolysis and degradation.