4-Chloro-1,5-naphthyridine

Basic Information

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CAS Number

7689-63-6

Molecular Formula

C8H5ClN2

Molecular Weight

164.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

102-103 ºC

Density

1.349

SMILES

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C1=CC2=NC=CC(=C2N=C1)Cl

InChI

InChI=1S/C8H5ClN2/c9-6-3-5-10-7-2-1-4-11-8(6)7/h1-5H

InChIKey

JECKUINVSSXFNR-UHFFFAOYSA-N

LogP

2.2832

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

140

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SCHEMBL11391
DTXSID50344365
AC-17206
7689-63-6
4-Chloro-[1,5]naphthyridine
1,5-Naphthyridine, 4-chloro-
AMY19119
CS-0050956
AS-38147
EN300-225589
A838889
MFCD07787239
4-Chloro-1,5-naphthyridine
8-Chloro-1,5-naphthyridine
SB15636
AKOS006287605
FT-0742836
4-Chlor-1,5-naphthyridin
4-Chlor-1,5-naphtyridin
4-chloranyl-1,5-naphthyridine
4-chloro-[1,5]naphthyridine
8-chloro-1,5-naphthyridine
4-chloro-1,5-naphthyridine

MDL Number

MFCD07787239

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 4-Chloro-1,5-naphthyridine (CAS: 7689-63-6)?

4-Chloro-1,5-naphthyridine is a crystalline compound with a molecular weight of 183.02 g/mol. It has a low solubility in water but good solubility in organic solvents. The compound shows moderate reactivity, particularly towards nucleophiles and bases, making it suitable for various synthetic transformations.

How is 4-Chloro-1,5-naphthyridine (CAS: 7689-63-6) typically synthesized?

4-Chloro-1,5-naphthyridine is commonly synthesized through the chlorination of 1,5-naphthyridine using thionyl chloride. The process involves the addition of thionyl chloride to a solution of 1,5-naphthyridine in an appropriate solvent, followed by heating to promote the chlorination reaction.

What industries use 4-Chloro-1,5-naphthyridine (CAS: 7689-63-6)?

4-Chloro-1,5-naphthyridine finds applications in the pharmaceutical industry, where it serves as a precursor for drug synthesis. It is also used in the chemical industry for the production of dyes and other organic compounds. Additionally, it is used in the polymer industry as a stabilizer and in the development of sensors.

What precautions should be taken when handling 4-Chloro-1,5-naphthyridine (CAS: 7689-63-6)?

When handling 4-Chloro-1,5-naphthyridine, protective equipment such as gloves, goggles, and a lab coat should be worn. The compound should be stored in a closed container and handled in a well-ventilated area or a fume hood. In case of a spill, immediately clean up the area and refer to the Safety Data Sheet (SDS) for detailed spill management instructions.