Natamycin | CAS No. 7681-93-8

Natamycin

Basic Information

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CAS Number

7681-93-8

Molecular Formula

C33H47O13N

Molecular Weight

665.73 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

280-300°C

Boiling Point

952.2°C at 760 mmHg

Density

1.0 g/mL at 20 °C

Flash Point

>110°(230°F)

Solubility

Soluble in DMSO

Refractive Index

1.5960 (estimate)

Specific Rotation

+278° (c=1, CH3COOH)

SMILES

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CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O

InChI

InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1

InChIKey

NCXMLFZGDNKEPB-FFPOYIOWSA-N

LogP

0.11970000000000391

Topological Polar Surface Area

230.98999999999998 Å²

Hydrogen Bond Donor/Acceptor

8 / 14

Complexity

1220

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Light sensitive

Sensitiveness

Light Sensitive

Toxicity

LD50 orally in male, female rats (g/kg): 2.73, 4.67 (Levinskas)

Synonyms & References

English

DTXCID301163
7681-93-8
Natamicina [INN-Spanish]
CL 12625
EINECS 231-683-5
CL 12,625
CHEBI:7488
NATAMYCIN
NSC 759167
DTXCID501473823
Myprozine
NATAMYCIN [INN]
NATAMYCIN [MART.]
(1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0~5,7~]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
BDBM50370755
NS00003340
NATAMYCIN (MART.)
NICOTINAMIDE_ADENINE_DINUCLEOTIDE
SCHEMBL18140
NATAMYCIN [ORANGE BOOK]
Natacyn
HY-B0133
EN300-22411493
CL-12625
Natamycin, Pharmaceutical Secondary Standard; Certified Reference Material
Delvocid
NATAMYCIN [WHO-DD]
Natajen
Natamycinum
CAS-7681-93-8
Natamycin [USAN:USP:INN:BAN]

MDL Number

MFCD00135085

FAQ

What is Natamycin (CAS: 7681-93-8)?

Natamycin, with the CAS number 7681-93-8, is a polyene antifungal antibiotic produced by the fermentation of *Streptomyces natalensis*. It has the chemical formula C33H52N10O14 and appears as a white to pale yellow powder. Natamycin is known for its broad-spectrum antifungal activity and is resistant to degradation by many common enzymes, making it suitable for various applications.

What are the main uses of Natamycin (CAS: 7681-93-8)?

Natamycin is primarily used in food preservation as a natural antimicrobial agent, particularly for inhibiting mold and yeast growth on dairy products and other perishables. It also finds applications in pharmaceuticals for treating fungal infections and in research for studying antifungal mechanisms. Additionally, it is used in industrial settings for surface disinfection and biocidal purposes.

Is Natamycin (CAS: 7681-93-8) safe?

Natamycin is generally considered safe when used as intended. It is approved by the FDA and other regulatory bodies for food and pharmaceutical use. However, proper handling is necessary to avoid inhalation or skin contact, especially during manufacturing. Safety data sheets recommend protective measures such as gloves and ventilation to ensure safe use and storage.

How should Natamycin (CAS: 7681-93-8) be stored?

Natamycin should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is stable under these conditions and should be kept in a sealed container to prevent moisture and contamination. Avoid exposure to high humidity, direct sunlight, and extreme temperatures to maintain its efficacy and integrity.