Amantadine (1-Adamantanamine)

Basic Information

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CAS Number

768-94-5

Molecular Formula

C10H17N

Molecular Weight

151.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

206-208 °C

Boiling Point

263.29°C (rough estimate)

Density

0.9510 (rough estimate)

Water Solubility

Soluble in organic solvents. Insoluble in water.

Flash Point

96 °C

Solubility

1 M HCl: soluble5%, clear to hazy, colorless to faint yellow or tan

Refractive Index

1.5220 (estimate)

SMILES

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NC1(CC2CC3CC(C2)C1)C3

InChI

1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2

InChIKey

DKNWSYNQZKUICI-UHFFFAOYSA-N

LogP

1.9139

pKa

10.1(at 25℃)

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

144

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Adamantan-1-amine
1-Adamantanamine
1-Aminoadamantane
Symadine
Symmetrel
Tricyclo[3.3.1.1(3,7)]decane-1-amine
Amantadine
1-Adamantanamine (purified by sublimation)
1-ADAMANTAMINE
1-Adamantylamine
ADAMANTANAMINE, 1-(SG)
1-adamantaneamine
1-aminoadamantine
Adamantanamine
Aminoadamantane
Pk-merz
1-Adamantylamine (purified by sublimation)
Amantadine (purified by sublimation)
1-Aminoadamantane (purified by sublimation)
Hawthorn P.E.
Adamantylamine
Adamantamine
Amantidine
Amantadinum
Amantadina
Amantadine Base
Amantadine [INN:BAN]
Amantadinum [INN-Latin]
Amantadina [INN-Spanish]
adamantan-1-ylamine
Gocovri

MDL Number

MFCD00074732

FAQ

What is Amantadine (CAS: 768-94-5)?

Amantadine, also known as 1-Adamantanamine (CAS: 768-94-5), is a cyclic tertiary amine compound primarily used in medicine. It has the chemical formula C13H19N and is characterized by its adamantane ring structure, which provides unique physical and chemical stability. Amantadine is known for its antiviral and antiparkinsonian properties, making it a versatile compound in pharmaceutical applications.

What are the main uses of Amantadine (CAS: 768-94-5)?

Amantadine (CAS: 768-94-5) is mainly used as an antiviral medication to treat influenza A and as a treatment for Parkinson’s disease. It is also utilized in research for its neuroprotective effects and in industrial settings as a chemical intermediate. Its applications span across pharmaceuticals, neuroscience, and chemical synthesis, making it a valuable compound for diverse fields.

Is Amantadine (CAS: 768-94-5) safe?

Amantadine (CAS: 768-94-5) is generally considered safe when used as directed, but it can have side effects such as insomnia, nausea, and hallucinations. It is important to follow safety guidelines, including proper handling and storage, to minimize risks. Safety standards for Amantadine are established by regulatory bodies to ensure appropriate use and reduce potential toxicity.

How should Amantadine (CAS: 768-94-5) be stored?

Amantadine (CAS: 768-94-5) should be stored in a cool, dry, and dark place, away from moisture and light. It is best kept in a sealed container at a temperature below 25°C. Proper storage ensures stability and prevents degradation, which is crucial for maintaining its efficacy and safety in both laboratory and pharmaceutical environments.