5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide | CAS No. 76712-82-8

5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide

Basic Information

CAS Number

76712-82-8

Molecular Formula

C66H86N18O12

Molecular Weight

1323.53 g/mol

AD

Basic Physical Properties

Boiling Point

1800.6°C at 760 mmHg

Density

1.46

Flash Point

1042.8°C

Specific Rotation

D20 -33.9° (c = 1 in acetic acid)

CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8

InChI

InChI=1S/C66H86N18O12/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81,90)(H,82,91)(H4,67,68,71)/t47-,48-,49-,50-,51-,52-,53+,54-,55-/m0/s1

InChIKey

HHXHVIJIIXKSOE-QILQGKCVSA-N

LogP

-0.7870300000000028

Topological Polar Surface Area

446.8599999999999 Ų

Hydrogen Bond Donor/Acceptor

17 / 30

Complexity

2660

Synonyms & References

English

  • Supprelin
  • (Des-Gly10,D-His(Bzl)6,Pro-NHEt9)-LHRH
  • SCHEMBL22288995
  • H50H3S3W74
  • 5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TYROSYL-NT-BENZYL-D-HISTIDYL-L-LEUCYL-L-ARGINYL-N-ETHYL-L-PROLINAMIDE
  • Luteinizing hormone-releasing factor (pig), 6-(1-(phenylmethyl)-D- histidine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-
  • HY-P0056
  • IBHPE-LHRH
  • imbzl-His(6), Pro(9)-NET-GNRH
  • Histrelinum (Latin)
  • histrelin
  • 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-Ntau-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
  • 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N(sup tau)-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
  • ((ImBl)-D-His(sub 6),Pro(sub 9)-NEt)LHRH
  • 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N(sup tau)- benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
  • HISTRELIN [INN]
  • 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
  • HISTRELIN [USAN]
  • des-gly10,(D-his(bzl)6)-lh-rh*ethylamide
  • Histrelin (USAN/INN)
  • RWJ 17070
  • SCHEMBL19712198
  • D02369
  • L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-N(im)-benzyl-histidyl-L-leucyl-L-arginyl-L-proline ethylamide
  • HISTRELIN (MART.)
  • AKOS030573448
  • DTXCID00150034
  • RWJ-17070
  • GTPL3884
  • Histrelinum [Latin]
  • CHEBI:5739

MDL Number

MFCD00133494

FAQ

What regulatory guidelines apply to 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 76712-82-8)?

The regulatory guidelines for 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 76712-82-8) vary depending on the intended use. It is important to adhere to Occupational Safety and Health Administration (OSHA) standards, Environmental Protection Agency (EPA) regulations, and REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) guidelines in the European Union. The compound should also comply with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) standards. For specific guidance, consult the Material Safety Data Sheet (MSDS) and local regulations.

Are there alternatives to 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide in synthesis?

There are several alternatives to 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 76712-82-8) in synthesis. These include using isomers or analogs with similar functional groups. Common alternative reagents include D-benzyl-L-histidine and related peptides. It is crucial to evaluate the chemical properties and efficacy of these alternatives to ensure they meet the desired application requirements.

What is the market or research trend for 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 76712-82-8)?

The market for 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 76712-82-8) shows increasing interest due to its potential applications in pharmaceutical research. Research trends indicate a focus on understanding its mechanisms of action and exploring its therapeutic potential. Additionally, there is growing interest in the development of related peptides for various medical applications.

How should waste containing 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 76712-82-8) be handled?

Waste containing 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 76712-82-8) should be handled with care to ensure environmental safety. The waste should be collected in sealed, leak-proof containers and stored in a secure location. For disposal, it is recommended to contact a licensed hazardous waste management company. Proper incineration or professional waste disposal is essential to prevent environmental contamination. Always refer to the Material Safety Data Sheet (MSDS) for specific disposal instructions and local regulations.

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