Leucine-enkephalin, arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gly-

Basic Information

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CAS Number

76622-26-9

Molecular Formula

C130H184N38O31S2

Molecular Weight

2839.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)C(C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NCC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)NC(=O)C(CC8=CC=CC=C8)NC(=O)CNC(=O)CNC(=O)C(CC9=CC=C(C=C9)O)N

InChI

InChI=1S/C130H184N38O31S2/c1-70(2)108(167-118(191)88(28-16-52-144-129(138)139)157-112(185)86(26-14-50-142-127(134)135)156-116(189)91(47-55-200-3)159-119(192)95(58-71-19-6-5-7-20-71)153-103(174)67-148-102(173)66-149-109(182)82(132)57-72-31-37-77(169)38-32-72)125(198)150-68-104(175)152-93(29-17-53-145-130(140)141)126(199)168-54-18-30-100(168)124(197)161-90(44-46-105(176)177)115(188)164-98(62-76-65-147-84-24-11-9-22-81(76)84)122(195)165-97(61-75-64-146-83-23-10-8-21-80(75)83)121(194)160-92(48-56-201-4)117(190)166-99(63-106(178)179)123(196)163-96(60-74-35-41-79(171)42-36-74)120(193)158-89(43-45-101(133)172)114(187)154-85(25-12-13-49-131)111(184)155-87(27-15-51-143-128(136)137)113(186)162-94(110(183)151-69-107(180)181)59-73-33-39-78(170)40-34-73/h5-11,19-24,31-42,64-65,70,82,85-100,108,146-147,169-171H,12-18,25-30,43-63,66-69,131-132H2,1-4H3,(H2,133,172)(H,148,173)(H,149,182)(H,150,198)(H,151,183)(H,152,175)(H,153,174)(H,154,187)(H,155,184)(H,156,189)(H,157,185)(H,158,193)(H,159,192)(H,160,194)(H,161,197)(H,162,186)(H,163,196)(H,164,188)(H,165,195)(H,166,190)(H,167,191)(H,176,177)(H,178,179)(H,180,181)(H4,134,135,142)(H4,136,137,143)(H4,138,139,144)(H4,140,141,145)/t82-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,108-/m0/s1

InChIKey

QYDAFJUKVGVEKO-PKOVDKIBSA-N

LogP

-6.904219999999909

Topological Polar Surface Area

1149.2099999999998 Å²

Hydrogen Bond Donor/Acceptor

50 / 69

Complexity

6360

Synonyms & References

English

Bam-22P
MFCD00076690
AKOS024456725
BAM-22P (H-L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Arg-L-Val-Gly-L-Arg-L-Pro-L-Glu-L-Trp-L-Trp-L-Met-L-Asp-L-Tyr-L-Gln-L-Lys-L-Arg-L-Tyr-Gly-OH)
Bovine adrenal medullary peptide-22P
Glycine, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-alpha-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-
Bam 22P
DTXSID40227451
76622-26-9
BAM 22 (1-22)
Leucine-enkephalin, arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gly-
Arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gly-lys-arg-tyr-gly-leu-enkephalin
PD079103
Leu-enkephalin, arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gly-lys-arg-tyr-gly-
Met-enkephalin-arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gln-lys-arg-tyr-gly-
Glycine,L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-a-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-a-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-
BAM 22P
BAM-22P
Glycine,L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-a...
Glycine,L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-a-glutamyl-L-
Glycine,L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-a-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-a-aspartyl-L-tyrosyl-L-glutaminyl-L-l
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-TRP-TRP-MET-ASP-TYR-GLN-LYS-ARG-TYR-GLY
H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH

MDL Number

MFCD00076690

FAQ

What are the physical and chemical properties of Leucine-enkephalin (CAS: 76622-26-9)?

Leucine-enkephalin (CAS: 76622-26-9) is a peptide with a molecular weight of approximately 754.75 g/mol. It is a white to off-white crystalline powder with good solubility in water but has limited solubility in organic solvents. It is stable under normal conditions but can degrade under acidic or basic conditions. It is reactive towards proteases and has limited reactivity towards other common chemical reagents.

How is Leucine-enkephalin (CAS: 76622-26-9) typically synthesized?

Leucine-enkephalin (CAS: 76622-26-9) is typically synthesized through solid-phase peptide synthesis (SPPS). The synthesis involves the stepwise addition of amino acids to a growing peptide chain on a solid support, with appropriate protecting groups. Commonly used coupling agents include DCC (dicyclohexylcarbodiimide) and HOBt (1-hydroxybenzotriazole). The yield is typically around 70-80%, with good selectivity towards the desired product.

What industries use Leucine-enkephalin (CAS: 76622-26-9)?

Leucine-enkephalin (CAS: 76622-26-9) is primarily used in the pharmaceutical industry for research purposes, including drug discovery and development. It is also used in the biochemical and biotechnology sectors for various applications such as enzyme studies and peptide-based assays. Limited applications are found in the polymer and semiconductor industries due to its specific biological activity.

What precautions should be taken when handling Leucine-enkephalin (CAS: 76622-26-9)?

When handling Leucine-enkephalin (CAS: 76622-26-9), it is important to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Store it in a cool, dry place away from direct sunlight. Use a fume hood for any handling that may generate vapors. In case of spills, neutralize with an appropriate reagent and dispose of according to local regulations. Always consult a Material Safety Data Sheet (MSDS) for specific handling instructions and emergency procedures.