(2R,6S)-2,6-dimethylpiperidine | CAS No. 766-17-6

Q: What are the physical and chemical properties of (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6)?

(2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6) is a crystalline solid with a molecular weight of approximately 112.22 g/mol. It has a melting point of 56-58°C and is slightly soluble in water but more soluble in organic solvents like ethanol. Chemically, it exhibits moderate reactivity, particularly in its ring-opening reactions and substitution reactions.

Q: How is (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6) typically synthesized?

(2R,6S)-2,6-dimethylpiperidine is typically synthesized via the reduction of dimethyl-2,6-dimethylcyclohexanone or by the hydroamination of 2,6-dimethylcyclohexane with an amine. These processes yield the compound with high selectivity and moderate to good yields, depending on the specific conditions and catalysts used.

Q: What industries use (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6)?

(2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6) is used in various industries, including pharmaceuticals for drug synthesis, polymers for producing plasticizers and adhesives, sensors for detecting specific gases, and semiconductors for surface treatments and dopants.

Q: What precautions should be taken when handling (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6)?

When handling (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6), ensure proper personal protective equipment (PPE) such as gloves, goggles, and lab coat. Store the compound in a cool, dry place away from direct sunlight and combustible materials. In case of a spill, use appropriate spill response gear and refer to the Safety Data Sheet (SDS) for specific instructions on cleanup procedures.

(2R,6S)-2,6-dimethylpiperidine

Basic Information

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CAS Number

766-17-6

Molecular Formula

C7H15N

Molecular Weight

113.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

<-20°C

Boiling Point

127°C

Density

0.84

Flash Point

16 ºC

Refractive Index

1.4394

SMILES

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CC1CCCC(N1)C

InChI

InChI=1S/C7H15N/c1-6-4-3-5-7(2)8-6/h6-8H,3-5H2,1-2H3/t6-,7+

InChIKey

SDGKUVSVPIIUCF-KNVOCYPGSA-N

LogP

1.5369

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

62.8

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 3.1 Class 3.1

Synonyms & References

English

(2R,6S)-2,6-dimethylpiperidine
AS-81925
SPBio_002652
cis-2,6-Dimethylpiperidine, 98%
NCGC00016653-02
Prestwick2_000666
A838770
CAS-5072-45-7
E79217
Prestwick3_000666
piperidine, 2,6-dimethyl-, (2R,6S)-
CHEMBL1517793
DTXSID30859422
Piperidine, 2,6-dimethyl-, (2R,6S)-rel-
cis-Lupetidine
(2S,6R)-2,6-dimethylpiperidine
NCGC00016653-01
cis-2,6-Lupetidine
BPBio1_000805
cis-Hexahydro-2,6-lutidine
Z1203730759
InChI=1/C7H15N/c1-6-4-3-5-7(2)8-6/h6-8H,3-5H2,1-2H3/t6-,7
Prestwick0_000666
cis-2,6-Dimethylpiperidine 766-17-6
766-17-6
AKOS006349672
Piperidin, 2e,6e-dimethyl
MFCD00066304
SCHEMBL83612
Prestwick1_000666
cis-2,6-Dimethylpiperidine

MDL Number

MFCD00066304

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6)?

(2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6) is a crystalline solid with a molecular weight of approximately 112.22 g/mol. It has a melting point of 56-58°C and is slightly soluble in water but more soluble in organic solvents like ethanol. Chemically, it exhibits moderate reactivity, particularly in its ring-opening reactions and substitution reactions.

How is (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6) typically synthesized?

(2R,6S)-2,6-dimethylpiperidine is typically synthesized via the reduction of dimethyl-2,6-dimethylcyclohexanone or by the hydroamination of 2,6-dimethylcyclohexane with an amine. These processes yield the compound with high selectivity and moderate to good yields, depending on the specific conditions and catalysts used.

What industries use (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6)?

(2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6) is used in various industries, including pharmaceuticals for drug synthesis, polymers for producing plasticizers and adhesives, sensors for detecting specific gases, and semiconductors for surface treatments and dopants.

What precautions should be taken when handling (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6)?

When handling (2R,6S)-2,6-dimethylpiperidine (CAS: 766-17-6), ensure proper personal protective equipment (PPE) such as gloves, goggles, and lab coat. Store the compound in a cool, dry place away from direct sunlight and combustible materials. In case of a spill, use appropriate spill response gear and refer to the Safety Data Sheet (SDS) for specific instructions on cleanup procedures.