Enalaprilat (Enalapril EP Impurity C)

Basic Information

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CAS Number

76420-72-9

Molecular Formula

C18H28N2O7

Molecular Weight

348.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

148-151°C

Water Solubility

Soluble in water with heating (~60°C)

Specific Rotation

D -67.0° (0.1M HCl)

SMILES

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C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CCC[C@H]2C(=O)O

InChI

InChI=1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1

InChIKey

MZYVOFLIPYDBGD-MLZQUWKJSA-N

LogP

1.1261000000000003

Topological Polar Surface Area

106.94000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

490

Synonyms & References

English

ENALAPRILAT HYDRATE
ENALAPRILAT USP(CRM STANDARD)
Enalaprilic Acid
N-[(1S)-1-(Carboxy)-3-phenylpropyl]-L-alanyl]-L-proline Dihydrate
Vasotec IV
(2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
Enalapril acid
(S)-1-[N-[1-(CARBOXY)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE, DIHYDRATE
1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline
Enalapril diacid
enalaprilate
L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-,(S)
N-(1(S)-carboxy-3-phenylpropyl)-L-alanyl-L-proline
S-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline
DMDC
Enalaprilat
(2S)-1-(2S)-2-{(1S)-1-carboxy-3-phenylpropylamino}propanoylpyrrolidine-2-carboxylic acid
(2S)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl] pyrrolidine-2-carboxylic acid

MDL Number

MFCD00865786

Customs Code

2933990090

FAQ

What regulatory guidelines apply to Enalaprilat (CAS: 76420-72-9)?

Enalaprilat (CAS: 76420-72-9) must adhere to regulatory guidelines such as the Chemical Abstracts Service (CAS), REACH regulations for European manufacturers, and FDA/EPA requirements for its manufacture, distribution, and use. It is classified under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) and requires appropriate handling, storage, and labeling.

Are there alternatives to Enalaprilat (CAS: 76420-72-9) in synthesis?

Alternatives to Enalaprilat (CAS: 76420-72-9) in synthesis include using enalaprilat itself or its precursors like enalapril, which are commonly used for the synthesis of angiotensin-converting enzyme (ACE) inhibitors. Other reagents like benzyloxycarbonyl-(β-methyl-δ-thiazol-5-yl)alanine methyl ester (CMBME) can also be considered as substitutes.

What is the market or research trend for Enalaprilat (CAS: 76420-72-9)?

The market for Enalaprilat (CAS: 76420-72-9) is closely associated with the cardiovascular health market, particularly in the treatment of hypertension. Research trends are shifting towards understanding its mechanisms and exploring potential new applications in other areas of drug development. Market trends show a steady demand driven by its role in managing arterial hypertension.

How should waste containing Enalaprilat (CAS: 76420-72-9) be handled?

Waste containing Enalaprilat (CAS: 76420-72-9) should be collected in appropriate containers and handled according to local and international hazardous waste regulations. Incineration is a common method, but professional waste disposal services should be utilized to ensure compliance. Environmental protection measures should include proper ventilation and adherence to safety guidelines to prevent contamination and ensure worker safety.