Enalapril maleate salt

Basic Information

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CAS Number

76095-16-4

Molecular Formula

C24H32N2O9

Molecular Weight

492.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

143-153°C

Boiling Point

0°C

Water Solubility

Soluble in water, methanol, and ethanol.

Flash Point

0°C

Solubility

methanol: ≥50 mg/mL, clear, colorless to yellow

Specific Rotation

-40.0° - -44.0° (c=1, MeOH)

SMILES

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OC(=O)/C=C\C(=O)O.CCOC(=O)[C@@H](N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C)CCc1ccccc1

InChI

InChI=1S/C20H28N2O5.C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25;5-3(6)1-2-4(7)8/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,16-,17-;/m0./s1

InChIKey

OYFJQPXVCSSHAI-QFPUQLAESA-N

LogP

1.3164000000000027

pKa

pKa1 3.0; pKa2 (25°) 5.4

Topological Polar Surface Area

170.54 Å²

Hydrogen Bond Donor/Acceptor

4 / 11

Complexity

519

Safety Information

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GHS Hazard Pictograms

H303

Hazard Statement

H303 May be harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

Enalapril maleate
(s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline (z)-2-butenedioate salt
(S)-1-[N-[1-(ETHOXYCARBONXYL)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE
[S]-1-[N-(1-[ETHOXYCARBONYL]-3-PHENYLPROPYL)-6-ALANYL]-L-PROLINE MALEATE
N-[[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE MALEATE(1: 1)
MK-421
CARDIOVET
BITENSIL
(S)-1-((S)-2-((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl)pyrrolidine-2-carboxylic acid compound with maleic acid (1:1)
(S,S,S)-Enalapril Maleate
1-(2-{[1-(Ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl)proline maleate
Enalapril (maleate)
Enalapril maleate salt
(S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt
1-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-L-proline Maleate
enalapril
Enalaprilum
Vasotec
Enalaprila
Enalapril Richet
69PN84IO1A
Enalaprilum [INN-Latin]
Enalaprila [INN-Spanish]
GBXSMTUPTTWBMN-XIRDDKMYSA-N
Enalapril [INN:BAN]
DSSTox_CID_2982
1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester
DSSTox_RID_76817
DSSTox_GSID_22982
Epaned
L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-

MDL Number

MFCD00133304

Customs Code

2933990090

FAQ

What is Enalapril maleate salt (CAS: 76095-16-4)?

Enalapril maleate salt is a medication used primarily for treating hypertension and heart failure. It is an angiotensin-converting enzyme (ACE) inhibitor, with the chemical formula C18H27N3O5·C3H6O3. It is a white to off-white crystalline powder that is soluble in water and has a molecular weight of 485.47 g/mol.

What are the main uses of Enalapril maleate salt (CAS: 76095-16-4)?

Enalapril maleate salt is mainly used in pharmaceuticals to manage high blood pressure (hypertension) and heart failure. It works by relaxing blood vessels and reducing the workload on the heart. It is also prescribed for patients with left ventricular dysfunction following a heart attack, and as part of treatment for chronic kidney disease.

Is Enalapril maleate salt (CAS: 76095-16-4) safe?

Enalapril maleate salt is generally safe when used as directed, but it may cause side effects such as dizziness, cough, or hyperkalemia. It is important to follow safety guidelines and consult a healthcare professional before use. Handling should be done with care, and proper protective measures should be taken to avoid exposure.

How should Enalapril maleate salt (CAS: 76095-16-4) be stored?

Enalapril maleate salt should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 30°C (59°F to 86°F) and a relative humidity below 60%. Ensure the container is airtight and protected from moisture to maintain stability and potency.