1-(2-Pyrimidinyl)methanamine

Basic Information

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CAS Number

75985-45-4

Molecular Formula

C5H7N3

Molecular Weight

109.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

179.9℃ at 760 mmHg

SMILES

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C1=CN=C(N=C1)CN

InChI

InChI=1S/C5H7N3/c6-4-5-7-2-1-3-8-5/h1-3H,4,6H2

InChIKey

ROSKZJGILXBSFM-UHFFFAOYSA-N

LogP

-0.0647000000000002

Topological Polar Surface Area

51.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

58.7

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

PD049642
AM20100741
BCP27503
(2-PYRIMIDINYLMETHYL)AMINE
ROSKZJGILXBSFM-UHFFFAOYSA-N
Pyrimidin-2-ylmethanamine
2-PYRIMIDINEMETHANAMINE
(pyrimidin-2-yl)methanamine
pyrimidin-2-ylmethylamine
2-aminomethyl-pyrimidine
2-(Aminomethyl)pyrimidine
60348-81-4
SY019710
AKOS009123469
pyrimidine 2-ylmethylamine
SCHEMBL244917
EN300-149197
CS-W008578
2-pyrimidinemethanamine, AldrichCPR
MFCD06212857
DS-10502
75985-45-4
2-Aminomethylpyrimidine
A15793
PB23443
NS00040721
J-524135
DTXSID20405311
F2147-1534
FT-0646813
PYRIMIDIN-2-YL-METHYLAMINE

MDL Number

MFCD06212857

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 1-(2-Pyrimidinyl)methanamine (CAS: 75985-45-4)?

1-(2-Pyrimidinyl)methanamine (CAS: 75985-45-4) is a colorless solid with a crystalline form. Its molecular weight is approximately 149.14 g/mol. This compound has a solubility of about 1.6 g/100 mL in water at 25°C. It is relatively stable under normal conditions but can react with strong acids or bases. The compound is not typically flammable but may release toxic gases upon reaction with strong oxidizers.

How is 1-(2-Pyrimidinyl)methanamine (CAS: 75985-45-4) typically synthesized?

1-(2-Pyrimidinyl)methanamine (CAS: 75985-45-4) can be synthesized through the reaction of 2-pyrimidinemethanamine with an appropriate amine. Common methods include the reaction of 2-pyrimidinemethanol with methylamine in the presence of an acid catalyst. This process typically yields a high selectivity and good yield.

What industries use 1-(2-Pyrimidinyl)methanamine (CAS: 75985-45-4)?

1-(2-Pyrimidinyl)methanamine (CAS: 75985-45-4) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also has applications in the polymer industry, where it can be used as a precursor for the production of functional polymers. Additionally, it has potential uses in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 1-(2-Pyrimidinyl)methanamine (CAS: 75985-45-4)?

When handling 1-(2-Pyrimidinyl)methanamine (CAS: 75985-45-4), it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should always be conducted in a fume hood to minimize exposure to toxic gases. Spills should be cleaned up using appropriate absorbent materials and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.