Afamelanotide | CAS No. 75921-69-6

Afamelanotide

Basic Information

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CAS Number

75921-69-6

Molecular Formula

C78H111N21O19

Molecular Weight

1646.85 g/mol

EINECS

211-519-9

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.46±0.1 g/cm3(Predicted)

Water Solubility

Soluble to 0.60 mg/ml in sterile water

SMILES

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CCCC[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CO)=O)CC1=CC=C(O)C=C1)=O)CO)=O)C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N2CCC[C@H]2C(N[C@H](C(N)=O)C(C)C)=O)=O)CCCCN)=O)=O)CC3=CNC4=CC=CC=C34)=O)CCCNC(N)=N)=O)CC5=CC=CC=C5)=O)CC6=CN=CN6)=O)CCC(O)=O)=O.O=C(O)C(F)(F)F

InChI

InChIKey

UAHFGYDRQSXQEB-LEBBXHLNSA-N

LogP

3.12050

pKa

4.43±0.10(Predicted)

Topological Polar Surface Area

680.2800000000002 Å²

Hydrogen Bond Donor/Acceptor

27 / 42

Complexity

3360

Synonyms & References

English

[NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE
(NLE4,D-PHE7)-ALPHA-MSH
[Nle4,D-Phe7]α-MSH
Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2
N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2
[Nle4,DPhe7] a-MSH, amide
[Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ
[Nle4, D-Phe7]-α-MSH, amide
Melanotan-1
Melanotropin
4-Nle-7-phe-alpha-msh
4-Norleucyl-7-phenylalanine-alpha-msh
[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt
(Nle?00D-Phe?)-α-MSH
(Nle⁴,D-Phe⁷)-α-MSH
[Nle4,D-Phe7]-α-MSH
Melanotan Ⅰ Acetate
Melanotan I
[Nle4, D-Phe7] ?-MSH NDP-MSH
Ac-Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Ac-SYS-Nle-EHfRWGKPV-NH2
MT-I
vial
Wiskostatin
Melanotan 1

MDL Number

MFCD00151715

EC Number

211-519-9

FAQ

What is Afamelanotide (CAS: 75921-69-6)?

Afamelanotide (CAS: 75921-69-6) is a synthetic analog of the melanocyte-stimulating hormone, specifically alpha-melanocyte-stimulating hormone (alpha-MSH). It is a peptide with the chemical formula C50H66N12O12S2 and is known for its melanin-producing properties. Afamelanotide is used in medical applications to regulate skin pigmentation and has been studied for its potential in treating conditions like erythropoietic protoporphyria.

What are the main uses of Afamelanotide (CAS: 75921-69-6)?

Afamelanotide (CAS: 75921-69-6) is primarily used in dermatology to manage skin sensitivity to sunlight, particularly in patients with erythropoietic protoporphyria. It also has applications in research related to skin pigmentation, hormonal regulation, and photoprotection. Its role in pharmaceutical development includes potential treatments for hyperpigmentation and sun-related skin disorders.

Is Afamelanotide (CAS: 75921-69-6) safe?

Afamelanotide (CAS: 75921-69-6) is generally considered safe when used as directed, with minimal systemic absorption. However, it should be handled with care to avoid contamination, and certain precautions are necessary during administration. Safety standards for Afamelanotide are established in pharmaceutical guidelines, emphasizing proper use and monitoring for adverse effects.

How should Afamelanotide (CAS: 75921-69-6) be stored?

Afamelanotide (CAS: 75921-69-6) should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 2°C to 8°C and requires protection from moisture and humidity. Proper storage in airtight containers is recommended to maintain its stability and effectiveness over time.