4-Chloro-2,5-dimethylpyrimidine

Basic Information

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CAS Number

75712-74-2

Molecular Formula

C6H7ClN2

Molecular Weight

142.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

82-83 ºC (17.5 Torr)

Density

1.184±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

88.5±7.4 ºC,

Refractive Index

1.5181 (589.3 nm 20 ºC)

SMILES

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CC1=CN=C(N=C1Cl)C

InChI

InChI=1S/C6H7ClN2/c1-4-3-8-5(2)9-6(4)7/h3H,1-2H3

InChIKey

QOKSKBJSPUYZAL-UHFFFAOYSA-N

LogP

1.74684

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

97.1

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

BS-35954
AKOS006283020
4-Chloro-2,5-dimethylpyrimidine
4-Chloro-2,5-dimethylpyrimidine, AldrichCPR
AB51539
75712-74-2
QOKSKBJSPUYZAL-UHFFFAOYSA-N
SY101579
Z1198223810
EN300-107352
Pyrimidine,4-chloro-2,5-dimethyl-(9ci)
DTXSID80499337
Pyrimidine, 4-chloro-2,5-dimethyl- (9CI)
FT-0716001
SCHEMBL3712628
MFCD09754455
CS-0045694
Pyrimidine,4-chloro-2,5-dimethyl-
4-Chlor-2,5-dimethyl-pyrimidin
4-Chloro-2,5-dimethyl-pyrimidine
4-chloro-2,5-dimethylpyrimidine(SALTDATA: FREE)
Pyrimidine,4-chloro-2,5-dimethyl

MDL Number

MFCD09754455

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 4-Chloro-2,5-dimethylpyrimidine (CAS: 75712-74-2)?

4-Chloro-2,5-dimethylpyrimidine is a white crystalline solid with a molecular weight of approximately 183.63 g/mol. It has a high melting point of 152-154°C and is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophiles. It is used as a building block in organic synthesis and pharmaceuticals.

How is 4-Chloro-2,5-dimethylpyrimidine (CAS: 75712-74-2) typically synthesized?

4-Chloro-2,5-dimethylpyrimidine is typically synthesized via the Wittig reaction or by the reduction of a corresponding N-protected pyrimidine. The Wittig reaction involves the condensation of a dialkylphosphite with a pyrimidine derivative. Alternatively, it can be obtained by reducing 2,5-dimethylpyrimidazine chloride using stannous chloride as a catalyst.

What industries use 4-Chloro-2,5-dimethylpyrimidine (CAS: 75712-74-2)?

4-Chloro-2,5-dimethylpyrimidine is used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It also finds applications in the polymer industry, particularly in the production of biodegradable polymers. Additionally, it is used in semiconductor manufacturing and as a sensor component in analytical chemistry.

What precautions should be taken when handling 4-Chloro-2,5-dimethylpyrimidine (CAS: 75712-74-2)?

When handling 4-Chloro-2,5-dimethylpyrimidine, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risks. If a spill occurs, neutralize it with an appropriate chemical and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.