4-Phenyl-1,3-thiazole-2-carbaldehyde

Basic Information

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CAS Number

75390-44-2

Molecular Formula

C10H7NOS

Molecular Weight

189.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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C1=CC=C(C=C1)C2=CSC(=N2)C=O

InChI

InChI=1S/C10H7NOS/c12-6-10-11-9(7-13-10)8-4-2-1-3-5-8/h1-7H

InChIKey

DJWIXPPOXVIXSZ-UHFFFAOYSA-N

LogP

2.6226000000000003

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

180

Synonyms & References

English

CS-0156391
FT-0691870
EN300-65675
SY106868
D82945
4-PHENYL-THIAZOLE-2-CARBALDEHYDE
75390-44-2
BB 0249283
4-phenyl-1,3-thiazole-2-carbaldehyde, AldrichCPR
Z1021388612
SCHEMBL2224538
4-phenyl-1,3-thiazole-2-carbaldehyde
4-Phenylthiazole-2-carbaldehyde
4-phenyl-2-thiazolecarboxaldehyde
A838399
4-phenyl-1,3-thiazole-2-carboxaldehyde
AB12112
MFCD02665589
AKOS001476298
AS-60499
DJWIXPPOXVIXSZ-UHFFFAOYSA-N
2-formyl-4-phenylthiazole
DTXSID20393446
2-Thiazolecarboxaldehyde,4-phenyl-
4-PHENYL-1,3-THIAZOLE-2-CARBALDEHYDE
4-phenyl-1,3-thiazole-2-carbaldehyde(SALTDATA: FREE)
4-Phenyl-2-Thiazolecarboxaldehyde
4-Phenyl-thiazol-2-carbaldehyd
BBL020795
2-Thiazolecarboxaldehyde, 4-phenyl-
STK893485

MDL Number

MFCD02665589

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 4-Phenyl-1,3-thiazole-2-carbaldehyde (CAS: 75390-44-2)?

4-Phenyl-1,3-thiazole-2-carbaldehyde is a crystalline solid with a molecular weight of approximately 218.23 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound exhibits good reactivity towards nucleophiles and is susceptible to electrophilic substitution reactions. It is also noted for its ability to form stable complexes with metal ions.

How is 4-Phenyl-1,3-thiazole-2-carbaldehyde (CAS: 75390-44-2) typically synthesized?

4-Phenyl-1,3-thiazole-2-carbaldehyde can be synthesized via the condensation of 1,3-thiazole-2-carbaldehyde and phenylisocyanide using a base like sodium hydride. The reaction yields a high purity product with good selectivity and a good yield of up to 85%. Chromatographic techniques such as silica gel column chromatography can be used for purification.

What industries use 4-Phenyl-1,3-thiazole-2-carbaldehyde (CAS: 75390-44-2)?

4-Phenyl-1,3-thiazole-2-carbaldehyde finds application in the pharmaceutical industry for the synthesis of drugs, particularly those targeting anti-inflammatory and anti-tumor activities. It is also used in the polymer industry as a monomer for the production of functionalized polymers. Additionally, it has applications in the development of sensors and materials for their electronics and semiconductor industries.

What precautions should be taken when handling 4-Phenyl-1,3-thiazole-2-carbaldehyde (CAS: 75390-44-2)?

Proper handling of 4-Phenyl-1,3-thiazole-2-carbaldehyde requires the use of personal protective equipment such as gloves, goggles, and a lab coat. This compound should be handled in a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Safety data sheets (SDS) should be consulted for detailed emergency response procedures and storage recommendations.