(2R)-2-Methylpiperazine

Basic Information

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CAS Number

75336-86-6

Molecular Formula

C5H12N2

Molecular Weight

100.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

91-93 °C

Boiling Point

155-156 ºC

Density

0.9305 (estimate)

Refractive Index

1.4378 (estimate)

Specific Rotation

-18 º (c=1, toluene)

SMILES

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CC1CNCCN1

InChI

InChI=1S/C5H12N2/c1-5-4-6-2-3-7-5/h5-7H,2-4H2,1H3/t5-/m1/s1

InChIKey

JOMNTHCQHJPVAZ-RXMQYKEDSA-N

LogP

-0.4323000000000001

Topological Polar Surface Area

24.06 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

Safety Information

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Hazard Statement

H228 Flammable solid
Flammable solids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 4.1 Class 4.1

Sensitiveness

Air Sensitive & Hygroscopic

Synonyms & References

English

(R)-2-methy 1-piperazine
(R)-2-methylpiperazin
(R)-(-)-2-methyl-piperazine
DTXSID30226296
M2091
2-Methylpiperazine, (R)-
(2R)-2-methyl-piperizine
(R)(-)-2-methylpiperazine
(R)-2-Methyl piperazine (L)tataric acid salt
(R)-2-Methyl-Piperazine
PIPERAZINE, 2-METHYL-, (2R)-
(R)-2-Methylpiperazine
(R)-3-Methylpiperazine
A801965
AKOS015840075
UNII-P4XU643R8W
2-(R)-methyl piperazine
JOMNTHCQHJPVAZ-RXMQYKEDSA-N
2(R)-methyl piperazine
PS-9320
BP-11286
(R)-(-)-2-Methylpiperazine
(R)-(-)-2-Methylpiperazine, 97%
P4XU643R8W
(R)-2-methyl piperazine
EN300-60346
R-(+)-2-Methylpiperazine
Q27286182
A9603
75336-86-6
(R)2-methylpiperazine

MDL Number

MFCD00192317

FAQ

What is (2R)-2-Methylpiperazine (CAS: 75336-86-6)?

(2R)-2-Methylpiperazine (CAS: 75336-86-6) is a chiral piperazine derivative with the chemical formula C5H12N2. It features a six-membered piperazine ring substituted with a methyl group at the second carbon, exhibiting specific stereochemical configuration (2R). This compound is commonly used as an intermediate in organic synthesis and has applications in pharmaceutical and chemical research due to its versatile structure and reactivity.

What are the main uses of (2R)-2-Methylpiperazine (CAS: 75336-86-6)?

(2R)-2-Methylpiperazine (CAS: 75336-86-6) is primarily utilized in pharmaceutical development as a building block for drugs targeting neurological disorders, such as antipsychotics and antihistamines. It also serves as a ligand in coordination chemistry and is applied in agrochemicals and industrial processes. Its unique stereochemistry makes it valuable for creating enantiomer-specific compounds, enhancing efficacy in medicinal applications.

Is (2R)-2-Methylpiperazine (CAS: 75336-86-6) safe?

The safety of (2R)-2-Methylpiperazine (CAS: 75336-86-6) depends on handling conditions. While it is generally considered low toxicity in controlled environments, prolonged exposure may cause irritation. Safety standards recommend using appropriate PPE (gloves, goggles, lab coat) and working in well-ventilated areas. Always follow OSHA guidelines and consult safety data sheets for specific precautions.

How should (2R)-2-Methylpiperazine (CAS: 75336-86-6) be stored?

(2R)-2-Methylpiperazine (CAS: 75336-86-6) should be stored in a cool, dry place (ideally 2-8°C), protected from light, and in a sealed container to prevent moisture absorption. It is stable under normal storage conditions but should be kept away from strong oxidizers or acids. Ensure storage in a well-ventilated area to maintain safety and chemical integrity.