(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate | CAS No. 75330-75-5

(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate

Basic Information

CAS Number

75330-75-5

Molecular Formula

C24H36O5

Molecular Weight

404.55 g/mol

AD

Basic Physical Properties

Physical State

Powder

Melting Point

179°C

Boiling Point

559.198℃/760mmHg

Density

1.1200

Water Solubility

0.0004 mg/mL at 25 ºC

Flash Point

185.3℃

Solubility

ethanol: soluble9.80-10.20mg/mL, clear, colorless to faintly yellow

Refractive Index

320 ° (C=0.5, CH3CN)

Vapor Pressure

2.22X10-12 mm Hg at 25 °C (est)

Specific Rotation

D25 +323° (c = 0.5 g in 100 ml acetonitrile)

CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

InChI

InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

InChIKey

PCZOHLXUXFIOCF-BXMDZJJMSA-N

LogP

4.195500000000004

Topological Polar Surface Area

72.83 Ų

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

666

Safety Information

View Safety Information

GHS Hazard Pictograms

H302H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class 9 Class 9

Storage Conditions

-20℃

Toxicity

LD50 orally in mice: >1000 mg/kg (Endo)

Synonyms & References

English

  • Lovastatin
  • [1s-[1alpha(r*),3alpha,7beta,8beta(2s*,4s*),8abeta]]-2-methylbutanoicacid1,2,
  • 4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha-(r*),3
  • 4-hydroxy-6-oxo-2h-pyran-2-yl]ethyl]-1-naphthalenyl(s)-2-methyl-butyrate
  • 8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthale
  • Mevinolin
  • MEVINOLIN(AS)
  • DL-Lactic acid
  • LOVALIP
  • LOVASTIN
  • MEVACOR
  • mevlor
  • msd803
  • Paschol
  • Rovacor
  • Sivlor
  • 6α-Methylcompactin
  • Monacolin K
  • 1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate
  • 洛伐他汀
  • Lovalord
  • Mevinacor
  • Altoprev
  • Nergadan
  • Artein
  • Altocor
  • 6alpha-Methylcompactin
  • Hipovastin
  • Lovastatine
  • Lovasterol
  • Lipivas

MDL Number

MFCD00072164

Customs Code

2932999099

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