sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate

Basic Information

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CAS Number

75277-39-3

Molecular Formula

C8H17N2NaO4S

Molecular Weight

260.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

234 °C

Density

1.1140

Water Solubility

It is soluble in water.

Solubility

H2O: 1 M at 20 °C, clear, colorless

SMILES

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C1CN(CCN1CCO)CCS(=O)(=O)[O-].[Na+]

InChI

InChI=1S/C8H18N2O4S.Na/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14;/h11H,1-8H2,(H,12,13,14);/q;+1/p-1

InChIKey

RDZTWEVXRGYCFV-UHFFFAOYSA-M

pKa

7.5(at 25℃)

Complexity

272

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents.

Sensitiveness

Hygroscopic

Synonyms & References

English

Q27120698
sodium N'-hydroxyethyl-N-piperazineethanesulfonate
4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid hemisodium salt
SY018360
A838366
HEPES sodium salt, Vetec(TM) reagent grade, 96%
CS-0029103
Tox21_302155
EINECS 278-169-7
AKOS015897769
HEPES sodium salt, 98%
CHEBI:46758
AKOS015964204
AKOS015912229
N-2-Hydroxyethylpiperazine-N'-2-ethanesulphonic acid hemisodium salt
HEPES sodium salt
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, monosodium salt
Z9FTO91O8A
HEPES sodium salt, biochemical grade
HEPES (sodium)
SCHEMBL229142
N-(2-Hydroxyethyl)piperazine-N'-(2-ethanesulfonic acid) sodium salt
CHEMBL3187284
NCGC00255791-01
Sodium2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate
N-(2-Hydroxyethyl)piperazine-N-(2-ethanesulfonicacid)hemisodiumsalt
HEPES sodium salt, BioPerformance Certified, suitable for cell culture, >=99.5%
sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate;Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate
HEPES sodium salt, BioXtra, >=99.0% (titration)
W-104397
75277-39-3

MDL Number

MFCD00036463

Customs Code

29335995

FAQ

What is sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate (CAS: 75277-39-3)?

Sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate (CAS: 75277-39-3) is a zwitterionic buffer commonly used in pharmaceutical and research applications. Its chemical formula is C8H17NO5S, and it has a pH buffering range of 6.5–7.5. It is highly soluble in water, making it suitable for use in aqueous solutions. Known as tromethamine, it is a key component in many formulations due to its stability and biocompatibility.

What are the main uses of sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate (CAS: 75277-39-3)?

Sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate (CAS: 75277-39-3) is primarily used as a pH buffer in pharmaceuticals, cosmetics, and medical solutions. It stabilizes drug formulations, maintains optimal pH in eye drops and injectables, and is employed in research for buffering biological samples. Additionally, it finds applications in industrial processes requiring controlled pH environments.

Is sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate (CAS: 75277-39-3) safe?

Sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate (CAS: 75277-39-3) is generally considered safe when handled according to standard protocols. It has low acute toxicity and is non-irritating to skin and eyes in recommended concentrations. Safety standards emphasize proper storage, avoiding inhalation, and using protective gloves. Regulatory bodies like the FDA approve its use in pharmaceutical applications, ensuring compliance with safety guidelines.

How should sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate (CAS: 75277-39-3) be stored?

Sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate (CAS: 75277-39-3) should be stored in a cool, dry place, away from light. Keep in airtight containers to prevent moisture absorption and contamination. It remains stable at room temperature for extended periods but should be protected from high humidity and extreme temperatures to maintain its efficacy and shelf life.