1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone | CAS No. 75001-82-0
1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone
Basic Information
CAS Number
75001-82-0
Molecular Formula
C15H18FN3O
Molecular Weight
275.33 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
218.5-220.0 ºC
Density
1.211±0.06 g/cm3 (20 ºC 760 Torr),
Synonyms & References
English
- CHEMBL30227
- UNII-3DV73N84L5
- Decarboxyl Norfloxacin
- 4(1H)-Quinolinone, 1-ethyl-6-fluoro-7-(1-piperazinyl)-
- 1-ethyl-6-fluoro-7-piperazin-1-ylquinolin-4-one
- 1-Ethyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one
- 1-Ethyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one; Norfloxacin Imp. D (EP); Norfloxacin Impurity D
- SCHEMBL7262142
- Norfloxacin impurity D [EP IMPURITY]
- 75001-82-0
- 3DV73N84L5
- MBX-2201
- A900349
- 1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone
- Norfloxacin EP Impurity D
- Imp. D (EP): 1-Ethyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one
- Norfloxacin Impurity D
- Norfloxacin Impurity D(EP)
- 1-ethyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one
MDL Number
MFCD27967090
FAQ
What are the physical and chemical properties of 1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone (CAS: 75001-82-0)?
1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone is a crystalline solid with a molecular weight of approximately 323.19 g/mol. It has low solubility in water but is soluble in organic solvents like DMSO. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.
How is 1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone (CAS: 75001-82-0) typically synthesized?
1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone can be synthesized via a multi-step process involving the coupling of an ethyl derivative with 6-fluoro-7-aminopyridine followed by piperazine addition. The synthesis typically uses a palladium catalyst and requires careful temperature control. The overall yield is moderate, around 50-60%, and the method allows for good selectivity and purity of the product.
What industries use 1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone (CAS: 75001-82-0)?
1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone is primarily used in the pharmaceutical industry as an intermediate in the synthesis of anti-inflammatory and antiviral drugs. It also has potential applications in the production of sensors and semiconductors, although its use in these industries is less common compared to pharmaceuticals.
What precautions should be taken when handling 1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone (CAS: 75001-82-0)?
Handling 1-Ethyl-6-fluoro-7-(1-piperazinyl)-4(1H)-quinolinone should be done with appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and reported to the safety officer. Users should consult the Safety Data Sheet (SDS) for detailed guidelines and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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